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RXDX-106
SynDRA canonical compound SYN1969880 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | AXL | MET |
|---|
| Mechanism of action | AXL kinase inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- AXL kinase inhibitor
- MET INHIBITOR
- MERTK INHIBITOR
- AXL INHIBITOR
- TYRO3 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CYP3A4
- BCL2
- BCL2L1
- CYP2C8
- KCNH2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Cross-references
Synonyms
- CEP-40783
- CEP40783
- UNII-1969ZJE05Q
- 1969ZJE05Q
- N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
- N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide
- RXDX-106 (CEP-40783)
- SCHEMBL16089863
- BCP25839
- EX-A2540
- MFCD28502441
- NSC797770
- s8570
- AKOS032960472
- ZINC205893112
- CCG-270157
- CS-6371
- NSC-797770
- SB18930
- AC-31425
- AS-35141
- HY-100946
- N-(4-((6,7-Dimethoxy-4-quinolinyl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-5-pyrimidinecarboxamide
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