asymmetrical-dimethylarginine

SynDRA canonical compound SYN0087349 — structure-anchored drug synonym record

Clinical phase	Phase 1
Primary target(s)	NOS3
Mechanism of action	Dimethylarginine dimethylaminohydrolase inhibitor

All known targets

NOS2
NOS3

Mechanisms of action (all sources)

Nitric oxide synthase inhibitor
Dimethylarginine dimethylaminohydrolase inhibitor
NOS2 INHIBITOR
NOS3 INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

Cross-references

PubChem CID: 123831
ChEMBL: CHEMBL457530
DrugBank: DB01686
ChEBI: 17929
KEGG: C03626
PDB: DA2
Wikipedia: Asymmetric_dimethylarginine
TTD: D02DQQ
LINCS BRD: BRD-K36269323

Synonyms

N,N-Dimethylarginine
ADMA
Asymmetric dimethylarginine
Dimethyl-L-arginine
NG,NG-dimethyl-L-arginine
N(G)-Dimethylarginine
N(G),N(G)-Dimethylarginine
Guanidino-N,N-dimethylarginine
N(G1),N(G1)-Dimethylarginine
N(5)-((Dimethylamino)iminomethyl)-L-ornithine
L-NG,NG-dimethylarginine
CHEBI:17929
(2S)-2-amino-5-(1,1-dimethylcarbamimidamido)pentanoic acid
N(5)-[(dimethylamino)(imino)methyl]-L-ornithine
N(5)-((dimethylamino)(imino)methyl)-L-ornithine
RefChem:560286
DTXCID4016758
Guanidino-N(1),N(1)-Dimethylarginine
L-Ornithine, N5-((dimethylamino)iminomethyl)-
(S)-2-Amino-5-(3,3-dimethylguanidino)pentanoic acid
NG,NG-dimethylarginine
MFCD00038406
N(omega),N(omega)-dimethyl-L-arginine
NG,NG-dimethyl-L-Arginine (hydrochloride)
NG,NG-DIMETHYLARGININE HYDROCHLORIDE
N~5~-(N,N-dimethylcarbamimidoyl)-L-ornithine
Lopac-D-4268
UNII-63CV1GEK3Y
Nomega,Nomega-Dimethyl-L-arginine
NG-dimethylarginine
L-Arg(Me, Me)-OH (asymmetrical)
n-n-dimethylarginine
N5-[(Dimethylamino)iminomethyl]-L-ornithine
Assymetric Dimethylarginine
Lopac0_000388
ADMA, 3
N,N-DIMETHYL-ARGININE
SCHEMBL196828
SCHEMBL995818

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