dactinomycin

SynDRA canonical compound SYN0086993 — structure-anchored drug synonym record

Primary target(s)	POLR2A
Mechanism of action	RNA polymerase inhibitor

All known targets

POLR2A

Mechanisms of action (all sources)

RNA polymerase inhibitor

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

ALDH1A1
ATXN2
TDP1
TARDBP
SMN1
PIN1
NFE2L2
MBNL1
MAPT
MAPK1
KDM4E
KDM4A
HPGD
GNAS
GMNN
GLP1R
GBA1
GAA
EYA2
EHMT2
BAZ2B
VDR

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

ABC3G
DRD3
FUS
G3P
GPR151
GSTO1
PAFA
PHGDH
PTBP1

Cross-references

PubChem CID: 45006140
ChEBI: 91853
LINCS BRD: BRD-A73909368

Synonyms

SR-05000001547
CHEBI:91853
HMS2091C17
Pharmakon1600-00330001
NSC755841
CCG-213691
NSC-755841
SBI-0206669.P002
AB01563171_01
SR-05000001547-1
SR-05000001547-2
BRD-A73909368-001-01-5
2-amino-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboxylic acid bis[1-[10,13-dimethyl-2,5,8,11,14-pentaoxo-3,9-di(propan-2-yl)-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-6-yl]ethyl] ester

Look up dactinomycin in the interactive SynDRA portal →