bortezomib

SynDRA canonical compound SYN0086822 — structure-anchored drug synonym record

Primary target(s)	PSMB5
Mechanism of action	NFKB pathway inhibitor

All known targets

PSMB1
PSMB2
PSMB5

Mechanisms of action (all sources)

proteasome inhibitor
NFKB pathway inhibitor

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

ALDH1A1
FLT3
VDR
SMN1
RELA
PSMB5
PSMB2
NFKBIA
MDM2
HSPA6
HDAC6
FXN
ESR1
CAPN2
ENGASE
EHMT2
CTSS
CTSL
CTSK
CTSB
CFTR
CFL1
CDK9
CAPN9
XPO1

Cross-references

PubChem CID: 73707406
ChEBI: 94645
LINCS BRD: BRD-K50691590

Synonyms

CHEBI:94645
PD063252
BRD-K50691590-001-01-4
BRD-K88510285-001-22-8
BRD-K88510285-001-25-1
[(1S)-1-[[(2R)-2-(1,4-dihydropyrazine-2-carbonylamino)-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid

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