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GR-235
SynDRA canonical compound SYN0086637 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | NR1H4 |
|---|
| Mechanism of action | Progesterone receptor agonist |
|---|
All known targets
- NR1H4
- ESR1
- IKBKB
- NR1I2
- PGR
Mechanisms of action (all sources)
- NR1H4 ANTAGONIST
- ESR1 AGONIST
- PGR AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- APEX1
- ATAD5
- POLI
- POLH
- PIN1
- NFE2L2
- MBNL1
- MAPT
- KDM4E
- KDM4A
- IDH1
- HDAC6
- GLI2
- CYP3A4
- CYP2D6
- CYP2C9
- CYP2C19
- CYP1A2
- CGA
- BAZ2B
- ATXN2
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP1A2
- CP2C9
- CP2CJ
- CP3A4
- DUS3L
- IDHC
- KCNH2
- KSYK
- PE2R2
- SC5A7
- SYK
Cross-references
Synonyms
- z-guggulsterone
- (-)-(E)-Guggulsterone (Standard)
- MFCD01310757
- SCHEMBL177528
- (E)-Guggulsterone (Standard)
- orb1301679
- GLXC-14909
- AKOS024456912
- SY103001
- NS00030501
- (17Z)-Pregna-4,17(20)-diene-3,16-dione
- (Z)-Guggulsterone
Look up GR-235 in the interactive SynDRA portal →