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sunitinib
SynDRA canonical compound SYN0042679 — structure-anchored drug synonym record
| Primary target(s) | RET |
|---|
| Mechanism of action | RET tyrosine kinase inhibitor |
|---|
All known targets
- FLT3
- FLT4
- KDR
- KIT
- PDGFRB
- RET
- FGFR1
- FLT1
- LATS1
- LATS2
- PDGFRA
Mechanisms of action (all sources)
- KIT INHIBITOR
- FLT3 INHIBITOR
- PDGFR inhibitor
- VEGFR inhibitor
- RET tyrosine kinase inhibitor
- FGFR1 INHIBITOR
- FLT4 INHIBITOR
- KDR INHIBITOR
- LATS1 INHIBITOR
- LATS2 INHIBITOR
- PDGFRB INHIBITOR
- RET INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABL1
- PAK4
- MST1R
- NEK2
- NEK4
- NTRK1
- NTRK2
- NTRK3
- PAK1
- PBK
- MINK1
- PDPK1
- PHKG2
- PIM1
- PIM2
- PIM3
- PKN2
- PLK1
- MKNK2
- MET
- MAP3K20
- MAPK8
- MAP4K4
- MAP4K5
- MAPK1
- MAPK10
- MAPK12
- MAPK13
- MAPK14
- MAPK9
- MELK
- MAPKAPK2
- MAPKAPK3
- MAPKAPK5
- MARK2
- MARK3
- MARK4
- MATK
- PLK3
- PLK4
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AAPK1
- KS6B1
- VGFR2
- TSSK1
- TP53
- TFE3
- ST17A
- PGFRB
- NTMT1
- NTM1A
- MP2K2
- MP2K1
- MITF
- M4K5
- M4K4
- KS6A5
- ATXN2
- KS6A4
- KPCD2
- KPCD
- KKCC2
- KCC2G
- KCC2D
- KCC2B
- KCC2A
- KCC1A
- KC1G3
- KC1G2
- KC1G1
- KC1D
- VGFR3
Cross-references
Synonyms
- sunitinib-malate
- Kinome_3835
- SCHEMBL8082
- SCHEMBL30314241
- WINHZLLDWRZWRT-UHFFFAOYSA-N
- GLXC-90222
- HMS3741I19
- SB65174
- NCGC00164631-03
- FS181808
- DB-000535
- Sunitinib Impurity 23(Sunitinib Mixture Of E And Z Isomer)
- N-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
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