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carfilzomib
SynDRA canonical compound SYN0041977 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PSMB10 |
|---|
| Mechanism of action | Proteasome inhibitor |
|---|
| Indication | multiple myeloma |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- PSMB9
- PSMB8
- PSMB5
- PSMB2
- PSMB10
- PSMB1
- PSMB7
- PSMA8
- PSMB6
- PSMB4
- PSMB3
- PSMB11
Mechanisms of action (all sources)
- proteasome inhibitor
- PSMD1 INHIBITOR
- PSMB2 INHIBITOR
- PSMB1 INHIBITOR
- PSMB5 INHIBITOR
- PSMB8 INHIBITOR
- PSMB9 INHIBITOR
- PSMB6 INHIBITOR
- PSMD14 INHIBITOR
- PSMA1 INHIBITOR
- PSMA2 INHIBITOR
- PSMA3 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CYP3A4
- CASP3
- CAPN1
- MYC
- MMP12
- MDM2
- HDAC6
- F2
- DPP4
- CYP2D6
- CAPN2
- CYP2C9
- CYP2C8
- CYP2C19
- CYP1A2
- CTSG
- CTSA
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ABCB5
- IFNG
- MDR1
- MITF
- NF2L2
- NR1I2
- NSD2
- PARP1
- PRGR
- RARA
- SMAD2
- SMAD3
- SNCA
- SYK
- SYUA
- TFE3
- TP53
- KSYK
- IFNB1
- ANDR
- HSPB1
- ATAD5
- ATXN2
- CASP7
- CP19A
- CP3A4
- CP3A7
- CREB1
- CYP3A43
- CYP3A5
- CYP3A7
- ESR1
- ESR2
- ESRRA
- GLI3
- HLAB
- VDR
Drug classes
- Proteasome Inhibitors
- Proteasome Inhibitor
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- KYPROLIS
- Kyprolis
- kyprolis
- PR 171
- NSC-758252
- PR-171
- Carfilzomib (PR-171)
- UNII-72X6E3J5AR
- 72X6E3J5AR
- CHEMBL451887
- CHEBI:65347
- NCGC00249613-01
- DSSTox_RID_82886
- DSSTox_CID_28616
- DSSTox_GSID_48690
- Carfilzomib (PR171)
- NSC 758252
- Carfilzomib [USAN]
- CAS-868540-17-4
- Carfilzomib [USAN:INN]
- MFCD11040997
- Kyprolis (TN)
- Carfilzomib; PR171
- CARFILZOMIB [MI]
- CARFILZOMIB [INN]
- CARFILZOMIB [JAN]
- CARFILZOMIB [VANDF]
- SCHEMBL85165
- CARFILZOMIB [WHO-DD]
- MLS006011102
- Carfilzomib (JAN/USAN/INN)
- GTPL7420
- DTXSID4048690
- AMY4357
- CARFILZOMIB [ORANGE BOOK]
- EX-A2037
- ONO-7057
Reported adverse events
- Asthenia
- Back pain
- Chest pain
- Chills
- Constipation
- Cough
- Dizziness
- Fatigue
- Headache
- Hypertension
- Influenza
- Insomnia
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