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leuprorelin
SynDRA canonical compound SYN0041802 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GNRH1 | GNRHR |
|---|
| Mechanism of action | gonadotropin releasing factor hormone receptor agonist |
|---|
| Indication | prostate cancer |
|---|
| Disease area | oncology |
|---|
All known targets
Mechanisms of action (all sources)
- GNRHR AGONIST
- Gonadotropin-releasing hormone receptor agonist
- gonadotropin releasing factor hormone receptor agonist
- GNRH1 ACTIVATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCC2
- OPRM1
- HTR1A
- HTR2B
- KCNH2
- KDR
- MAOA
- MRGPRX2
- PDE3A
- ACHE
- PDE4A
- PGR
- PTGS1
- SLC6A2
- SLC6A3
- SLC6A4
- HRH3
- HDAC6
- F2
- ESR1
- DRD3
- DRD1
- CYP3A4
- CYP2D6
- CYP2C9
- CYP2C19
- CYP1A2
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- ADORA3
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Gonadotropin Releasing Hormone Receptor Agonists
- Gonadotropin Releasing Hormone Receptor Agonist
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Fertility Agents, Female
- Reproductive Control Agents
ATC classes
- L02A · HORMONES AND RELATED AGENTS
Cross-references
Synonyms
- CAMCEVI ETM
- CAMCEVI KIT
- Camcevi
- ELIGARD KIT
- Eligard
- FENSOLVI KIT
- Fensolvi
- LEUPROLIDE ACETATE
- LEUPROLIDE ACETATE FOR DEPOT SUSPENSION
- LUPANETA PACK
- LUPRON
- LUPRON DEPOT
- leuprolide acetate
- eligard
- leupline
- leuprolide
- leuprorelin acetate
- leuprorelin mesilate
- Leuprolide
- Leuproreline
- Leuprorelina
- (-)-leuprolide
- Leuporelin
- Leuprorelin slow release
- ABBOTT-43818 FREE BASE
- CKD-841
- NSC-377526
- TAP-144 FREE BASE
- Leuprorelin acetate
- Leuprolide acetate
- Leuplin (TN)
- Leuprorelin acetate (JAN)
- 5-oxoPro-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-ProNHC2H5 dihydrate
- Enantone
- Eligard (TN)
- Leuprorelin (INN)
- Viadur (TN)
- 5-oxoprolylhistidyltryptophylseryltyrosylleucylleucyl-n5-(diaminomethylidene)ornithyl-n-ethylprolinamide
Reported adverse events
- Dizziness
- Fatigue
- Infection
- Headache
- Asthenia
- Constipation
- Depression
- Insomnia
- Rash
- Bone pain
- Cough
- Dysuria
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