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ciclosporin
SynDRA canonical compound SYN0041801 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PPP3CA |
|---|
| Mechanism of action | Calcineurin inhibitor |
|---|
| Indication | psoriasis | rheumatoid arthritis |
|---|
| Disease area | dermatology | rheumatology |
|---|
All known targets
- PPIA
- PPP3CA
- ABCB11
- SLCO1B3
- SLCO1B1
- SLC10A1
- PPID
- FPR1
- ABCB1
- TACR2
- Pik3cg
- PPP3R2
Mechanisms of action (all sources)
- calcineurin inhibitor
- PPIA MODULATOR
- Cyclophilin A modulator
- PPP3CA INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR2
- TACR1
- CYP2C19
- NR1I3
- NR1I2
- NR1H4
- ESR1
- RARB
- CRHR2
- ADRA1A
- HTR2A
- LCK
- JAK1
- NPSR1
- NPY1R
- NPY2R
- NR1H2
- NR1H3
- HTR7
- NFE2L2
- HTR6
- NR3C1
- NTSR1
- OPRD1
- OPRK1
- OPRM1
- NPC1
- NFATC1
- KCNH2
- MC3R
- LMNA
- MAOA
- MAPK1
- MAPK14
- MAPK3
- MAPT
- MC4R
- MTOR
- MC5R
- MLNR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP19A
- SO1B1
- PPP3CC
- PAX8
- NSD2
- NFKB1
- NF2L2
- MDR1
- MDM4
- MDM2
- IL1B
- GLI3
- FUS
- ESRRA
- EPAS1
- CYP3A43
- CRHBP
- CP3A4
- CP2CJ
- CP1A2
- SO1B3
Drug classes
- Calcineurin Inhibitor Immunosuppressant
- Calcineurin Inhibitors
- Cytochrome P450 3A4 Inhibitors
- P-Glycoprotein Inhibitors
- Anti-Infective Agents
- Antifungal Agents
- Antirheumatic Agents
- Dermatologic Agents
- Enzyme Inhibitors
- Immunologic Factors
- Immunosuppressive Agents
ATC classes
- S01X · OTHER OPHTHALMOLOGICALS
- L04A · IMMUNOSUPPRESSANTS
Cross-references
Synonyms
- Atopica
- CEQUA
- CYCLOSPORINE
- Cequa
- Cyclavance
- GENGRAF
- Gengraf
- NEORAL
- Neoral
- Optimmune
- RESTASIS
- RESTASIS MULTIDOSE
- neoral
- cyclosporine
- cyclosporin
- ciclosporine
- cyclosporin A
- Cyclosporine
- Ciclosporine
- Ciclosporina
- Cyclosporin a
- Ciclosporin a
- Ciclosporinum
- Cyclosporin
- Cyclosporine a
- Cyclosporine microemulsion
- Cyclosporine, modified
- Equoral
- Mitogard
- Neoplanta
- Neurostat
- Ramihyphin a
- Zinograf me
- 27-400
- ANTIBIOTIC S-7481F1
- NSC-290193
- OL-27-400
- SANG-35
Reported adverse events
- Headache
- Nausea
- Vomiting
- Abscess
- Acne
- Flushing
- Hepatotoxicity
- Hirsutism
- Hypertension
- Leukopenia
- Lymphoma
- Pneumonia
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