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vincristine
SynDRA canonical compound SYN0041761 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TUBB |
|---|
| Mechanism of action | Tubulin inhibitor |
|---|
| Indication | acute lymphoblastic leukemia (ALL) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- TUBB
- ABCB1
- ABCC1
- ABCC10
- ABCC2
- TUBA4A
- TUBB1
- TUBB2A
- TUBB2B
- TUBB3
- TUBB4A
- TUBB4B
Mechanisms of action (all sources)
- microtubule inhibitor
- tubulin polymerization inhibitor
- TUBB INHIBITOR
- TUBB1 INHIBITOR
- TUBB2A INHIBITOR
- TUBB2B INHIBITOR
- TUBB3 INHIBITOR
- TUBB4A INHIBITOR
- TUBB4B INHIBITOR
- TUBB6 INHIBITOR
- TUBB8 INHIBITOR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ABCB6
- MDM4
- TLR3
- TF65
- TACC3
- SYK
- RORA
- PAX8
- NSD2
- NR0B1
- MMP14
- MDR1
- MDM2
- ARNT
- KSYK
- IFNG
- HTR1E
- HIF1A
- GEMI
- CTNB1
- CSTA
- CFTR
- BRCA1
- BARD1
- YAP1
Drug classes
- Vinca Alkaloid
- Antimitotic Agents
- Antineoplastic Agents
- Antineoplastic Agents, Phytogenic
- Tubulin Modulators
ATC classes
- PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Cross-references
Synonyms
- (+)-Vincristine
- leucristine
- vincristin
- vinkristin
- 22-oxo-vincaleukoblastine
- vincristine sulfate
- oncovin
- 22-Oxovincaleukoblastine
- Leurocristine
- Vinkristin
- Vincrystine
- Vincristina [DCIT]
- rel-Vincristine
- Vincristinum [INN-Latin]
- Tecnocris
- CHEBI:28445
- NSC-67574
- Kyocristine
- Vincristine (INN)
- VIN
- NCGC00163700-01
- Vincrstine
- Oncotcs
- CAS-57-22-7
- Tecnocris (TN)
- LCR
- VCR
- Vincasar (1:1 sulfate salt)
- Oncovin (1:1 sulfate salt)
- Vincrex (1:1 sulfate salt)
- oncovin (brand name)
- SCHEMBL3709
- CHEMBL90555
- GTPL6785
- DTXSID1032278
- HMS2090E19
- Tox21_112067
- BDBM50139772
- ZINC85432549
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