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flurbiprofen axetil
SynDRA canonical compound SYN0041522 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS1 | PTGS2 |
|---|
| Mechanism of action | analgesic agent |
|---|
All known targets
- PTGS1
- PTGS2
- SLC36A1
- AKR1C2
- AKR1C3
- FABP2
- Fabp1
- Ptgs2
- Ptgs1
Mechanisms of action (all sources)
- PTGS2 INHIBITOR
- Cyclooxygenase inhibitor
- PTGS1 INHIBITOR
- SLC36A1 INHIBITOR
- PTGS2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- HTR2B
- SLC6A4
- SLC6A3
- SLC6A2
- PGR
- PDE4A
- PDE3A
- OPRM1
- MAOA
- KDR
- KCNH2
- HTR1A
- ADORA3
- HRH3
- F2
- ESR1
- DRD3
- DRD1
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Cyclooxygenase Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Central Nervous System Agents
- Enzyme Inhibitors
- Nonsteroidal Anti-inflammatory Drug
- analgesic agent
ATC classes
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
- S01B · ANTIINFLAMMATORY AGENTS
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
- R02A · THROAT PREPARATIONS
Cross-references
Synonyms
- ropiopn
- Ropion
- LFP-83
- FP-83
- I0OU31PUI5
- FP83
- DTXCID1028526
- RefChem:141041
- 1-Acetoxyethyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoate
- 1-acetyloxyethyl 2-(3-fluoro-4-phenylphenyl)propanoate
- 1-Acetoxyethyl-2-(2-fluoro-4-biphenylyl)propionate
- MFCD00900049
- Lipfen
- LFP 83;Ropiopn;LFP-83;LFP83
- Flurbiprofen axetil (JAN)
- FLURBIPROFEN AXETIL [JAN]
- Lipo-flurbiprofen axetil
- Liposomal flurbiprofen axetil
- CAS-91503-79-6
- C19H19FO4
- UNII-I0OU31PUI5
- LFP83
- NCGC00182710-01
- NCGC00182710-02
- Ropion (TN)
- orb1304142
- SCHEMBL1649401
- SCHEMBL29370747
- CHEBI:31627
- HMS5085J04
- MSK10984
- Tox21_113023
- AC-455
- FLURBIPROFEN AXETIL [WHO-DD]
- s6457
- AKOS024464989
- Tox21_113023_1
- DS-8257
Reported adverse events
- Bleeding
- GI bleed
- Ulceration
- Elderly
- Rash
- Hypertension
- Perforation
- Hepatotoxicity
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