← SynDRA
theophylline
SynDRA canonical compound SYN0041334 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PDE4B |
|---|
| Mechanism of action | Adenosine receptor antagonist |
|---|
| Indication | asthma | bronchitis | emphysema |
|---|
| Disease area | pulmonary |
|---|
All known targets
- ADORA1
- PDE3A
- ADORA2B
- ADORA3
- ADORA2A
- PDE4A
- PDE4B
- PDE3B
- PDE4D
- PDE4C
- PIK3CD
- PDE5A
Mechanisms of action (all sources)
- Adenosine receptor antagonist
- PDE4A INHIBITOR
- Phosphodiesterase 4 inhibitor
- PDE4D INHIBITOR
- PDE4B INHIBITOR
- PDE4C INHIBITOR
- PDE3A INHIBITOR
- Phosphodiesterase 3 inhibitor
- PDE3B INHIBITOR
- ADORA1 ANTAGONIST
- ADORA2B ANTAGONIST
- ADORA3 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- ACHE
- MAPK3
- KCNH2
- LCK
- LMNA
- MAOA
- MAPK1
- MAPK14
- MAPT
- HTR6
- MC3R
- MC4R
- MC5R
- MLNR
- MMP1
- MMP9
- IDH1
- HTR3A
- FLT1
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HIF1A
- HDAC6
- GNAS
- GMNN
- GHSR
- GCGR
- NPY1R
- NPY2R
- NR3C1
- SLCO1B3
- SLC22A7
- SLC29A1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Anti-Asthmatic Agents
- Bronchodilator Agents
- Cardiotonic Agents
- Cardiovascular Agents
- Enzyme Inhibitors
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Phosphodiesterase Inhibitors
- Protective Agents
- Purinergic Antagonists
- Purinergic P1 Receptor Antagonists
- Respiratory System Agents
ATC classes
- R03D · OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Cross-references
Synonyms
- ACCURBRON
- AEROLATE
- AEROLATE III
- AEROLATE JR
- AEROLATE SR
- AMINOPHYLLIN
- AMINOPHYLLINE
- AMINOPHYLLINE DYE FREE
- AMINOPHYLLINE IN SODIUM CHLORIDE 0.45%
- AMINOPHYLLINE IN SODIUM CHLORIDE 0.45% IN PLASTIC CONTAINER
- AQUAPHYLLIN
- ASBRON
- aminophyllin
- aminophylline
- 1,3-Dimethylxanthine
- armophylline
- cetraphylline
- chronophyllin
- duraphyllin
- elixophyllin
- elixophylline
- etheophyl
- lanophyllin
- pseudotheophylline
- theophyllin
- throphylline
- xanthium
- theophylline anhydrous
- aminophylline dihydrate
- theophylline sodium glycinate
- theophylline monohydrate
- THEOPHYLLINE ANHYDROUS
- Aminophylline
- Aminocardol
- Aminodur
- Aminofilina
- Aminofillina
- Aminophyllin
- Ammophyllin
Reported adverse events
- Vomiting
- Tremor
- Nervousness
- Rhabdomyolysis
- Disorientation
- Death
- Hypotension
- Seizure
- Atrial fibrillation
- Sinus tachycardia
- Ventricular arrhythmia
- Tachycardia
Look up theophylline in the interactive SynDRA portal →