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REPOTRECTINIB
SynDRA canonical compound SYN0039769 — structure-anchored drug synonym record
| Clinical phase | Phase 1/Phase 2 |
|---|
| Primary target(s) | ALK | ROS1 | SRC | TRK |
|---|
| Mechanism of action | receptor tyrosine protein kinase inhibitor |
|---|
All known targets
- ROS1
- NTRK1
- NTRK2
- NTRK3
- ALK
- CD74
- SDC4
- SRC
- TRK
Mechanisms of action (all sources)
- NTRK1 INHIBITOR
- Nerve growth factor receptor Trk-A inhibitor
- NTRK2 INHIBITOR
- Neurotrophic tyrosine kinase receptor type 2 inhibitor
- ROS1 INHIBITOR
- Proto-oncogene tyrosine-protein kinase ROS inhibitor
- NTRK3 INHIBITOR
- NT-3 growth factor receptor inhibitor
- CD74 INHIBITOR
- SDC4 INHIBITOR
- receptor tyrosine protein kinase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CYP2C9
- JAK2
- PTK2
- CYP1A2
- CYP2C19
- CYP2D6
- CYP3A4
- HDAC1
- HDAC2
- HDAC6
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CD74
- EML4
- HLAB
- IFNB1
- KSYK
- NSD2
- PARP1
- SLC34A2
- SYK
Drug classes
- Antineoplastic Agents
- Tyrosine Kinase Inhibitors
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- AUGTYRO
- Augtyro
- TPX-0005
- TRX-0005
- TPX 0005
- FIKPXCOQUIZNHB-RRKGBCIJSA-N
- SCHEMBL20438940
- BCP19778
- repotrectinibum
- RefChem:178876
- Multikinase Inhibitor TPX-0005
- Multi-kinase Inhibitor TPX-0005
- ALK/ROS1/NTRK/SRC/FAK Multikinase Inhibitor TPX-0005
- Ropotrectinib
- Repotrectinib [USAN]
- TPX0005
- Repotrectinib(TPX-005)
- Augtyro (TN)
- UNII-08O3FQ4UNP
- REPOTRECTINIB [INN]
- Repotrectinib (JAN/USAN)
- Repotrectinib (TPX-0005)
- REPOTRECTINIB [WHO-DD]
- orb1303198
- SCHEMBL16946804
- SCHEMBL29358351
- GTPL10316
- CHEBI:229220
- TPX 0005 [WHO-DD]
- BDBM374727
- CXC22002
- EX-A2572
- US10246466, Example 93
- NSC800522
- s8583
- AKOS037648789
- CCG-268096
- CS-7628
- NSC-800522
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