← SynDRA

SELITRECTINIB

SynDRA canonical compound SYN0039720 — structure-anchored drug synonym record

All known targets

• NTRK1
• NTRK2
• NTRK3

Mechanisms of action (all sources)

• NTRK1 INHIBITOR
• Neurotrophic tyrosine kinase receptor inhibitor
• NTRK2 INHIBITOR
• NTRK3 INHIBITOR
• tyrosine kinase inhibitor

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ALK
• ROS1
• ABL2
• PLK1
• PAK4
• PAK5
• PAK6
• PDGFRA
• PDGFRB
• PDK1
• PHKG2
• PIM1
• PIM2
• PIM3
• PKN2
• PLK2
• OGG1
• PLK3
• PRKACA
• PRKCA
• PRKCB
• PRKCD
• PRKCE
• PRKCH
• PRKCI
• PRKCQ
• PRKCZ
• PAK2
• NUAK1
• PRKD2
• NTHL1
• MAPKAPK5
• MARK1
• MARK2
• MBD4
• MELK
• MERTK
• MET
• MINK1
• MKNK2

Drug classes

• Enzyme Inhibitors

Cross-references

• PubChem CID: 129103609
• ChEMBL: CHEMBL4297627
• DrugBank: DB14896
• TTD: D03UDF

Synonyms

• LOXO-195
• LOXO 195
• OEBIHOVSAMBXIB-SJKOYZFVSA-N
• LOXO195
• UNII-0J45910S3X
• 0J45910S3X
• LOXO-195 (S racemic)
• SCHEMBL18823882
• EX-A1873
• HY-101977
• CS-0022378
• Cas registry number 2097002-61-2 ~1~1 C20 H21 F N6 O 10H-5,7-ethenopyrazolo(3,4-d)pyrido(2,3-k)pyrrolo(2,1-m)(1,3,7)triazacyclotridecin-10-one, 17-fluoro-1,2,3,11,12,13,14,18b-octahydro-12-methyl-, (12R,18bR)-
• 12H-15,17-Ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one, 5-fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-, (3aR,10R)-
• (13E,14E,22R,6R
• BAY-2731954
• selitrectinibum
• RefChem:182327
• TRK Inhibitor LOXO-195
• LOXO 195(Selitrectinib)
• Selitrectinib (LOXO-195)
• Selitrectinib(LOXO-195)
• MFCD31620755
• SelitrectinibLOXO-195
• Selitrectinib (Standard)
• SELITRECTINIB [INN]
• SELITRECTINIB [WHO-DD]
• C20H21FN6O
• orb1299822
• SCHEMBL29673979
• GTPL10314
• BDBM50507492
• NSC809970
• AKOS037648883
• HY-101977R
• NSC-809970
• AC-32662
• BS-15941
• DA-67532
• example 28 [WO2017075107A1]