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SEL-120 FREE BASE
SynDRA canonical compound SYN0039339 — structure-anchored drug synonym record
| Clinical phase | Phase 1 |
|---|
| Primary target(s) | CDK19 | CDK8 |
|---|
| Mechanism of action | cdk inhibitor |
|---|
| Indication | acute myeloid leukemia (aml) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
Mechanisms of action (all sources)
- CDK19 INHIBITOR
- CDK8 INHIBITOR
- cyclin-dependent kinase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CDK9
- CLK1
- CLK2
- CLK4
- CSNK1A1
- CSNK2A2
- CYP1A2
- DYRK1A
- HASPIN
- HIPK3
- KCNH2
- MAPK15
- PIM2
- ROCK1
- TAOK1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CCNA2
- CCNC
- CCNE1
- CCNH
- CDK2
- CDK5
- CDK5R1
- CDK7
- MNAT1
Cross-references
Synonyms
- Romaciclib
- UNII-6LGR0RYY5Q
- SEL120-34A free base
- CDK8-IN-2 free base
- 6LGR0RYY5Q
- RefChem:182254
- SEL120-34A
- romaciclib [INN]
- SEL120-34Afree
- CDK8-IN-2
- C15H18Br2N4
- orb1710104
- RVU120
- SCHEMBL17106044
- SCHEMBL29372569
- GTPL13753
- GLXC-90225
- EX-A2929
- JPC52233
- SEL-120-34A
- BDBM50459995
- MFCD31619286
- NSC805500
- AKOS040732774
- NSC-805500
- NCGC00590966-01
- AC-31560
- TS-07724
- HY-111388
- CS-0040310
- T10744
- SEL120-34A (monohydrochloride)
- UNII-SDM3M518PJ
- 7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-
- HY-111388A
- SEL120
- F981016
- SDM3M518PJ
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