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ENASIDENIB
SynDRA canonical compound SYN0039139 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | IDH1 |
|---|
| Mechanism of action | isocitrate dehydrogenase inhibitor |
|---|
| Indication | acute myeloid leukemia (AML) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- IDH2
- IDH1
- IDH3A
- IDH3B
- IDH3G
Mechanisms of action (all sources)
- IDH2 INHIBITOR
- Isocitrate dehydrogenase [NADP], mitochondrial inhibitor
- IDH2 BINDER
- isocitrate dehydrogenase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- ADORA1
- ADORA3
- TBXA2R
- PTGS1
- KCNH2
- HTR2B
- SLC6A4
- SLC6A3
- SLC6A2
- PGR
- PDE4A
- PDE3A
- OPRM1
- MAOA
- KDR
- HTR1A
- ACHE
- HRH3
- HDAC6
- F2
- ESR1
- DRD3
- DRD1
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- UGT1A1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Isocitrate Dehydrogenase 2 Inhibitors
- Isocitrate Dehydrogenase 2 Inhibitor
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- IDHIFA
- Idhifa
- enasidenib mesylate
- AG-221
- CC-90007 Free Base
- CC-90007
- AG-221 mesylate
- AG-221 (IDH2 inhibitor)
- ENASIDENIB MESYLATE
- UNII-UF6PC17XAV
- Enasidenib (mesylate)
- UF6PC17XAV
- Enasidenib mesylate [USAN]
- Enasidenib mesylate (USAN)
- Enasidenib mesilate
- Enasidenib methanesulfonate
- Idhifa (TN)
- SCHEMBL16448052
- HY-18690A
- CS-7541
- AG 221
- 3T1SS4E7AG
- enasidenibum
- CHEBI:145374
- RefChem:58279
- L01XX59
- DTXCID401513509
- idhifa
- AG-221 (Enasidenib)
- Enasidenib [INN]
- MFCD29472245
- UNII-3T1SS4E7AG
- AG221
- AG-221(Enasidenib)
- AG-221; Enasidenib
- Enasidenib; AG-221
- ENASIDENIB [MI]
- Enasidenib (USAN/INN)
Reported adverse events
- Dysgeusia
- Gastrointestinal disorder
- Nausea
- Vomiting
- Decreased appetite
- Differentiation syndrome
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