← SynDRA
TRILACICLIB
SynDRA canonical compound SYN0038619 — structure-anchored drug synonym record
| Clinical phase | Phase 2 |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | CDK4 | CDK6 |
|---|
| Mechanism of action | CDK inhibitor |
|---|
All known targets
- CDK4
- CDK6
- CDK2
- CDK7
- CDK9
- CDK1
- CDK5
- FLT3
- NEK10
- NUAK2
Mechanisms of action (all sources)
- CDK4/6 inhibitor
- Cyclin-dependent kinase 4 inhibitor
- Cyclin-dependent kinase 6 inhibitor
- CDK2 INHIBITOR
- CDK7 INHIBITOR
- CDK9 INHIBITOR
- cyclin-dependent kinase inhibitor
- CDK4 INHIBITOR
- CDK6 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABL1
- AURKA
- BRD4
- BRPF1
- CSNK1D
- FAP
- FGFR3
- GSK3B
- MAPK1
- TRIM24
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CCNA1
- CCNA2
- CCND1
- CCND3
- CCNE1
- CCNT1
Drug classes
- Kinase Inhibitor
- Organic Cation Transporter 2 Inhibitors
- Multidrug and Toxin Extrusion Transporter 1 Inhibitors
- Cyclin-dependent Kinase 4 Inhibitors
- Cyclin-dependent Kinase 6 Inhibitors
- Multidrug and Toxin Extrusion Transporter 2 K Inhibitors
- Protein Kinase Inhibitors
ATC classes
- V03A · ALL OTHER THERAPEUTIC PRODUCTS
Cross-references
Synonyms
- COSELA
- Cosela
- trilaciclib dihydrochloride
- cosela
- G1T28
- G1T28-1
- GB3RG-28-1
- G1t28-1
- Trilaciclib [USAN]
- G1T28(Trilaciclib)
- GTPL9626
- CHEMBL3894860
- SCHEMBL10082028
- BDBM253928
- US9464092, T
- HY-101467
- CS-0021431
- U6072DO9XG
- G-1T28
- trilaciclibum
- RefChem:58212
- DTXCID801767475
- G1T28; Cosela
- G1T28(Trilaciclib)?
- G1T28 di-HCl
- TRILACICLIB [INN]
- Trilaciclib (USAN/INN)
- UNII-U6072DO9XG
- TRILACICLIB [WHO-DD]
- orb1708328
- SCHEMBL29356370
- SCHEMBL29763763
- CHEBI:231087
- EX-A4297
- MFCD30747890
- NSC816987
- AKOS040740452
- EBC-171048
Reported adverse events
- Abdominal pain
- Abdominal pain upper
- Aspartate aminotransferase
- Aspartate aminotransferase increased
- Blood potassium decreased
- Fatigue
- Headache
- Hypersensitivity
- Pneumonia
- Pneumonitis
- Rash
- Thrombosis
Look up TRILACICLIB in the interactive SynDRA portal →