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ROLAPITANT
SynDRA canonical compound SYN0038480 — structure-anchored drug synonym record
| Clinical phase | Phase 3 |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | TACR1 |
|---|
| Mechanism of action | neurokinin receptor antagonist |
|---|
All known targets
Mechanisms of action (all sources)
- TACR1 ANTAGONIST
- Neurokinin 1 receptor antagonist
- neurokinin receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADGRF1
- ADRA2A
- TDG
- SMUG1
- S1PR1
- OGG1
- NTHL1
- NEIL2
- NEIL1
- MUTYH
- MPG
- GPR35
- GPR119
- GLP1R
- FPR2
- FFAR4
- CX3CR1
- C5AR2
- C5AR1
- C3AR1
- APLNR
- AGTR1
- ADRB2
- UNG
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Neurokinin 1 Antagonists
- Neurokinin-1 Receptor Antagonists
- Neurotransmitter Agents
- Substance P/Neurokinin-1 Receptor Antagonist
- Cytochrome P450 2D6 Inhibitors
- P-Glycoprotein Inhibitors
- Breast Cancer Resistance Protein Inhibitors
ATC classes
- A04A · ANTIEMETICS AND ANTINAUSEANTS
Cross-references
Synonyms
- VARUBI
- Varubi
- rolapitant hydrochloride
- varubi
- SCH619734
- SCH 619734
- Varuby
- SCH-619734
- UNII-NLE429IZUC
- NLE429IZUC
- Rolapitant [USAN:INN]
- Varubi (TN)
- Rolapitant (USAN/INN)
- Rolapitant(sch619734)
- SCHEMBL354305
- GTPL5749
- CHEMBL3707331
- CHEBI:90908
- DTXSID90203740
- MolPort-035-942-975
- EX-A1288
- BCP09609
- ZINC3816514
- rolapitantum
- RefChem:57237
- A04AD14
- DTXCID20126231
- sch-619734
- Rolapitant free base
- MFCD23105917
- Rolapitant [INN]
- Rolapitant?
- Rolapitant (Standard)
- ROLAPITANT [MI]
- ROLAPITANT [USAN]
- ROLAPITANT [WHO-DD]
- orb1303855
- C25H26F6N2O2
Reported adverse events
- Dizziness
- Dyspepsia
- Hiccups
- Neutropenia
- Stomatitis
- Decreased appetite
- Urinary tract infection
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