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LGH-447
SynDRA canonical compound SYN0038366 — structure-anchored drug synonym record
| Clinical phase | Phase 1 |
|---|
| Primary target(s) | PIM1 | PIM2 | PIM3 |
|---|
| Mechanism of action | Pim kinase inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- PIM1 INHIBITOR
- Serine/threonine-protein kinase PIM inhibitor
- PIM2 INHIBITOR
- PIM3 INHIBITOR
- Pim kinase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PRKCQ
- GSK3B
- PKN1
- SYK
- PAK4
- PIK3C2B
- PI4KB
- PHKG2
- PHKG1
- PDPK1
- PDGFRB
- PDGFRA
- PAK6
- PAK3
- PIK3C3
- PAK2
- PAK1
- OXSR1
- OGG1
- NUAK2
- NUAK1
- NTRK3
- NTRK2
- NTRK1
- PIK3C2G
- AAK1
- NR2F1
- PLK3
- PRKCH
- PRKCE
- PRKCD
- PRKCA
- PRKACB
- PRKACA
- PRKAA2
- PRKAA1
- PLK4
- PLK2
- PIK3CB
- PLK1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Cross-references
Synonyms
- LGH 447
- PIM KINASE INHIBITOR LGH447
- 5HZ
- CPD 8
- LGH447
- NVP-LGH477
- PIM-447
- PIM447
- VRQXRVAKPDCRCI-ZNMIVQPWSA-N
- PIM447 (LGH447)
- N-{4-[(1r,3s,5s)-3-Amino-5-Methylcyclohexyl]pyridin-3-Yl}-6-(2,6-Difluorophenyl)-5-Fluoropyridine-2-Carboxamide
- N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide
- UNII-9TG5O4V25H
- SCHEMBL3215332
- GTPL9790
- 9TG5O4V25H
- CHEMBL3651966
- PIM 447 [WHO-DD]
- BDBM106870
- ZINC116907270
- AKOS032945086
- CS-5929
- compound 8 [PMID: 26505898]
- HY-19322
- J3.552.648J
- US8592455, 70
- 5H7
- 2-Pyr
- PIM 447
- Pim kinase inhibitor lgh447
- RefChem:153262
- PIM447 dihydrochloride
- LGH447-(1S,3R,5R)
- LGH447 2HCl
- LGH-447 2HCl
- orb1708852
- SCHEMBL29379725
- PIM447; LGH447
- GLXC-10644
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