← SynDRA

ALVELESTAT

SynDRA canonical compound SYN0038341 — structure-anchored drug synonym record

All known targets

• ELANE

Mechanisms of action (all sources)

• ELANE INHIBITOR
• Leukocyte elastase inhibitor
• elastase inhibitor

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• HDAC6

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP3A7
• GPX4

Cross-references

• PubChem CID: 46861623
• ChEMBL: CHEMBL3617964
• DrugBank: DB11863
• TTD: D02PHE
• LINCS BRD: BRD-K31476763

Synonyms

• AZD9668
• MPH966
• AZD-9668
• MPH-966
• Alvelestat (AZD9668)
• CHEMBL3617964
• KB-105160
• Avelestat
• 6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-{[5-(methylsulfonyl)pyridin-2-yl]methyl}-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide
• 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide
• Alvelestat [INN]
• Alvelestat; AZD 9668
• avelestat-azd9668
• AZD9668;AZD-9668;AZD 9668
• Alvelestat (AZD9688)
• N-((5-(methanesulfonyl)pyridin-2-yl)methyl)-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide
• 6Y5629322X
• 6-methyl-5-(2-methylpyrazol-3-yl)-N-[(5-methylsulfonylpyridin-2-yl)methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide
• 3-pyridinecarboxamide, 1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)-2-pyridinyl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-
• UNII-6Y5629322X
• 3-PYRIDINECARBOXAMIDE, 1,2-DIHYDRO-6-METHYL-5-(1-METHYL-1H-PYRAZOL-5-YL)-N-((5-(METHYLSULFONYL)-2-PYRIDINYL)METHYL)-2-OXO-1-(3-(TRIFLUOROMETHYL)PHENYL)-
• 6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide
• N-{[5-(methanesulfonyl)pyridin-2-yl]methyl}-6-methyl-5-(1-methyl-1h-pyrazol-5-yl)-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide
• ALVELESTAT [WHO-DD]
• SCHEMBL560757
• GTPL6476
• DTXSID40233875
• BCP07945
• EX-A2004
• Alvelestat (AZD848141-11-7
• BDBM50120430
• ZINC72316197
• CS-1684
• DB11863
• SB19590
• NCGC00378593-01
• NCGC00378593-04
• NCGC00378593-05
• NCGC00378593-07