← SynDRA

BIRABRESIB

SynDRA canonical compound SYN0038318 — structure-anchored drug synonym record

All known targets

• BRD2
• BRD4
• BRD3
• BRDT
• SELE
• VCAM1

Mechanisms of action (all sources)

• BRD2 INHIBITOR
• Bromodomain and extra-terminal motif (BET) inhibitor
• BET bromodomain inhibitor
• BRDT INHIBITOR
• BRD3 INHIBITOR
• BRD4 MODULATOR
• BRD2 MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• EP300
• HDAC1
• HDAC6

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• NSD2

Cross-references

• PubChem CID: 9936746
• ChEMBL: CHEMBL3581647
• DrugBank: DB15189
• ChEBI: 230508
• KEGG: D10911
• PDB: 6JE
• Wikipedia: Birabresib
• TTD: D02YNI
• LINCS BRD: BRD-K43471985

Synonyms

• Y-803 anhydrous
• MK-8628
• OTX-015
• OTX-015 ANHYDROUS
• OTX015
• OTX015 ANHYDROUS
• MK 8628
• OTX 015
• OTX-015 anhydrous
• Birabresib [USAN]
• X40LKS49S3
• (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide
• 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6S)-
• OTX015 pound MK 8628/Birabresib pound(c)
• (S)-2-(4-(4-Chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]-triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetaMide
• 6H-Thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine-6-acetamide, 4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6S)-
• (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide.
• 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-hydroxyphenyl)acetamide
• 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-(4-hydroxyphenyl)acetamide
• UNII-X40LKS49S3
• MK-8628;Birabresib
• OTX015 (Birabresib)
• BIRABRESIB [INN]
• Birabresib (USAN/INN)
• BIRABRESIB [WHO-DD]
• GTPL8359
• SCHEMBL2898131
• CHEMBL3581647
• EX-A640
• CHEBI:191051
• DTXSID701103937
• ZINC3960759
• BDBM50092312
• MFCD26960949
• NSC778747
• s7360
• AKOS027323345
• CCG-264724