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LY-3009120
SynDRA canonical compound SYN0038313 — structure-anchored drug synonym record
| Clinical phase | Phase 1 |
|---|
| Primary target(s) | ARAF | BRAF | RAF1 |
|---|
| Mechanism of action | RAF inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- BRAF INHIBITOR
- Serine/threonine-protein kinase B-raf inhibitor
- RAF1 INHIBITOR
- Serine/threonine-protein kinase RAF inhibitor
- ARAF INHIBITOR
- Serine/threonine-protein kinase A-Raf inhibitor
- RAF inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABL1
- KDR
- SRC
- MAP4K5
- CSK
- MAP3K20
- EIF2AK4
- EPHA2
- EPHB4
- MAP3K1
- FYN
- MAP2K5
- KRAS
- IRAK1
- MAPK1
- GSK3B
- HDAC6
- AURKA
- FGFR2
- CSNK1D
- CDK2
- BRPF1
- BRD4
- TRIM24
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- KSYK
- MAPK10
- MAPK11
- MAPK12
- MAPK13
- MAPK14
- MAPK8
- MAPK9
- NSD2
- SYK
Cross-references
Synonyms
- Pan-raf inhibitor ly3009120
- DP-4978
- LY3009120
- DP 4978
- 1GDT36RARO
- CHEBI:167662
- RefChem:154569
- UNII-1GDT36RARO
- 4Z5
- MFCD28411374
- C23H29FN6O
- GTPL8943
- orb1300380
- SCHEMBL15241297
- SCHEMBL29356086
- SCHEMBL29479162
- GLXC-90494
- EX-A1638
- BDBM50096279
- DP4978
- NSC781761
- NSC801010
- s7842
- AKOS025396178
- CCG-268937
- EBC-221032
- NSC-781761
- NSC-801010
- SB16924
- NCGC00481604-01
- AC-30240
- AS-74984
- DA-75177
- FD103657
- HY-12558
- LY-3009120DP-4978
- LY3009120?
- T6882
- C72761
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