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BRIGATINIB
SynDRA canonical compound SYN0038271 — structure-anchored drug synonym record
| Clinical phase | Phase 2 |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | ALK | EGFR |
|---|
| Mechanism of action | ALK tyrosine kinase receptor inhibitor |
|---|
All known targets
- ALK
- EGFR
- IGF1R
- INSR
- ROS1
- FLT3
- NUAK1
Mechanisms of action (all sources)
- ALK INHIBITOR
- ALK tyrosine kinase receptor inhibitor
- EGFR INHIBITOR
- Epidermal growth factor receptor erbB1 inhibitor
- IGF1R INHIBITOR
- INSR INHIBITOR
- ALK MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABL1
- ERBB2
- FGFR4
- FGFR3
- FGFR2
- FGFR1
- FES
- FER
- PRKD1
- PRKD2
- PRKD3
- FLT4
- PTK2
- PTK2B
- PTK6
- RET
- RPS6KA1
- RPS6KA2
- RPS6KA3
- RPS6KA6
- FGR
- FRK
- SRC
- LRRK2
- MET
- MELK
- MARK3
- MARK2
- MARK1
- MAP3K9
- LYN
- LTK
- LCK
- FYN
- KIT
- KDR
- JAK2
- INSRR
- PHKG2
- HRH3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CD74
- CRBN
- EML4
- KAPCA
- KSYK
- NSD2
- PARP1
- PRKACA
- SDC4
- SLC34A2
- TP53
- VHL
Drug classes
- Tyrosine Kinase Inhibitors
- Kinase Inhibitor
- Cytochrome P450 3A Inducers
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- ALUNBRIG
- Alunbrig
- alunbrig
- AP26113
- AP-26113
- BRIGATINIB (AP-26113)
- BRIGATINIB (AP26113)
- BRIGATINIBAP-26113AP26113CS-4278
- UNII-HYW8DB273J
- Brigatinib [USAN]
- HYW8DB273J
- Brigatinib (USAN)
- Brigatiib
- Alunbrig (TN)
- Brigatinib [USAN:INN]
- Brigatinib (AP26113)
- SCHEMBL11916361
- KS-00000TSQ
- EX-A775
- MolPort-044-561-640
- BDBM50185140
- ZINC148723177
- AKOS030257612
- CS-4278
- DB12267
- HY-12857
- AC-29958
- ALK-IN-1
- UNII-3DGD69C6PV
- 3DGD69C6PV
- CHEMBL3397300
- AP26113-analog
- Tube723
- compound 11q [PMID: 27144831]
- Brigatinib(AP26113)
- SCHEMBL11916416
- DTXSID30725416
- EX-A770
Reported adverse events
- Abdominal pain
- Arthralgia
- Bradycardia
- Constipation
- Cough
- Dizziness
- Dysgeusia
- Dyspepsia
- Fatigue
- Headache
- Hypertension
- Insomnia
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