← SynDRA
RIBOCICLIB
SynDRA canonical compound SYN0038225 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | CDK4 | CDK6 | JAK3 |
|---|
| Mechanism of action | CDK inhibitor |
|---|
| Indication | breast cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- CDK4
- CDK6
- CAMK2D
- CAMK2G
- CDK16
- CDK2
- CDK9
- FECH
- GAK
- JAK3
- MAP3K1
- PRKD2
Mechanisms of action (all sources)
- CDK4/6 inhibitor
- Cyclin-dependent kinase 4 inhibitor
- Cyclin-dependent kinase 6 inhibitor
- cyclin-dependent kinase inhibitor
- CDK4 MODULATOR
- CDK6 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- YJ005
- SYK
- OGG1
- OLA1
- OPA1
- PAICS
- PAK2
- PAK4
- PASK
- NTRK1
- PCYT1A
- PDGFRB
- PDXK
- PEBP1
- PFKP
- PGRMC1
- PHKG2
- PIM1
- PIM2
- PIP4K2A
- PRKACG
- PRKCI
- PRKCD
- PRKCB
- PRKCA
- PRKAG2
- PRKAG1
- PRKACB
- PIP4K2C
- PRKACA
- PRKAA1
- PLK4
- PKN2
- PKN1
- PKMYT1
- NUAK2
- NTHL1
- PRKG1
- MARK3
- MELK
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CCND1
- CCND3
- CCNT1
- KSYK
- NSD2
Drug classes
- Kinase Inhibitors
- Kinase Inhibitor
- Cytochrome P450 3A Inhibitors
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- KISQALI
- KISQALI FEMARA CO-PACK (COPACKAGED)
- Kisqali
- ribociclib succinate
- LEE011
- LEE 011
- kisqali
- LEE011-BBA
- LEE011A
- LEE-011
- LEE-011A
- NVP-LEE011
- Ribociclib Succinate
- LEE011 succinate
- LEE011 (succinate)
- UNII-BG7HLX2919
- Ribociclib succinate [USAN]
- BG7HLX2919
- Kisqali (TN)
- Ribociclib succinate (USAN)
- LEE-011 succinate
- SCHEMBL2684999
- EX-A1586
- HY-15777B
- 1374639-75-4 (succinate)
- AKOS030526460
- CS-2277
- ACN-040739
- Ribociclib(LEE011)
- UNII-TK8ERE8P56
- TK8ERE8P56
- Ribociclib (LEE011)
- AK174906
- Ribociclib [USAN:INN]
- Tube013
- Ribociclib [INN]
- Ribociclib, LEE011
- Ribociclib-[d6]
Reported adverse events
- Infection
- Abdominal pain
- Alopecia
- Cough
- Fatigue
- Headache
- Nausea
- Neutropenia
- Rash
- Stomatitis
- Vomiting
- Back pain
Look up RIBOCICLIB in the interactive SynDRA portal →