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XL-228
SynDRA canonical compound SYN0038220 — structure-anchored drug synonym record
Clinical phase
Phase 1
Primary target(s)
AURKA | FGF2 | IGF1R | SRC
Mechanism of action
Abl kinase inhibitor | insulin growth factor receptor inhibitor | SRC inhibitor
All known targets
IGF1R
SRC
ABL1
BLK
FGR
FRK
FYN
HCK
LCK
LYN
SRMS
YES1
Mechanisms of action (all sources)
ABL1 INHIBITOR
Tyrosine-protein kinase ABL inhibitor
IGF1R INHIBITOR
Insulin-like growth factor I receptor inhibitor
FYN INHIBITOR
SRC inhibitor
LCK INHIBITOR
YES1 INHIBITOR
BLK INHIBITOR
HCK INHIBITOR
LYN INHIBITOR
FRK INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
AAK1
FLT3
ABL2
MAP4K5
MAP4K3
MAP4K2
MAP4K1
MAP3K11
MAP2K2
MAP2K1
LIMK1
IRAK3
INSR
IKBKE
FGFR1
CSNK2A2
FER
ERCC2
EPHB6
EPHB4
EPHB2
EPHA7
EPHA5
EPHA4
EPHA2
EPHA1
EIF2AK1
DDR2
MARK2
MARK3
MST1R
NTRK1
ULK3
TNK2
TNK1
TNIK
TGFBR1
TEC
TBK1
SYK
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
COMT
CP2D6
GAMT
GNMT
HLAB
HNMT
IFNB1
KSYK
NNMT
NSD2
NTM1A
NTMT1
PARP1
PNMT
TP53
Cross-references
PubChem CID:
59757974
ChEMBL:
CHEMBL3545085
DrugBank:
DB05184
TTD: D03ZXZ
Synonyms
Exel-2280
XL228
XL 228
UNII-33M2XSK003
33M2XSK003
4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine
SCHEMBL11342904
CHEMBL3545085
AOB5553
EX-A1596
BCP08143
ZINC203005669
AKOS030526975
CS-1648
NCGC00378978-05
SC-95574
AS-16897
HY-15749
AC-30228
2,4-Pyrimidinediamine, N(sup 4)-(5-cyclopropyl-1H-pyrazol-3-yl)-N(sup 2)-((3-(1-methylethyl)-5-isoxazolyl)methyl)-6-(4-methyl-1-piperazinyl)-
KB-303240
RefChem:902364
Tyrosine Kinase Inhibitor XL228
C22H31N9O
MFCD26793867
orb1307597
SCHEMBL29356150
GLXC-06661
YKB28007
NSC778366
NSC800970
s1272
NSC-778366
NSC-800970
XL-228?
NCGC00378978-03
DA-59189
X4400
F84974
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