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AT-13148
SynDRA canonical compound SYN0038179 — structure-anchored drug synonym record
| Clinical phase | Phase 1 |
|---|
| Primary target(s) | AKT1 | AKT2 | AKT3 | ROCK1 | ROCK2 | SGK3 |
|---|
| Mechanism of action | protein kinase inhibitor |
|---|
All known targets
- ROCK1
- ROCK2
- AKT1
- AKT2
- AKT3
- MAPK1
- MAPKAPK2
- SGK3
Mechanisms of action (all sources)
- ROCK2 INHIBITOR
- Rho-associated protein kinase inhibitor
- ROCK1 INHIBITOR
- MAPKAPK2 INHIBITOR
- MAP kinase-activated protein kinase 2 inhibitor
- MAPK1 INHIBITOR
- protein kinase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PRKACB
- SYK
- RPS6KA1
- RPS6KA3
- LATS1
- RPS6KA4
- RPS6KA5
- RPS6KA6
- RPS6KB1
- PKN1
- PKN2
- PRKCD
- GRK2
- PRKACA
- NUAK2
- NQO2
- NLK
- OLA1
- OPA1
- PAICS
- PAK2
- PDGFRB
- PAK4
- PCYT1A
- NEK3
- PDXK
- PEBP1
- PFKP
- PGRMC1
- PHKG2
- PIM1
- PIP4K2A
- PIP4K2C
- PKMYT1
- PLK4
- PRKAA1
- NEK9
- AAK1
- NEK2
- MARK2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- COMT
- CP2C9
- GAMT
- GNMT
- HLAB
- HNMT
- IFNB1
- KSYK
- NNMT
- NSD2
- PARP1
- PNMT
- PRKACG
- RPS6KA2
- RPS6KB2
Cross-references
Synonyms
- AT13148
- A49037RP1E
- RefChem:916440
- Multi-AGC Kinase Inhibitor AT13148
- UNII-A49037RP1E
- MFCD25976789
- RKD
- SCHEMBL851471
- orb1305420
- GLXC-04834
- EX-A1797
- BDBM50242733
- NSC771650
- NSC799337
- s7563
- AKOS024258899
- CCG-267617
- CS-3136
- EBC-157201
- NSC-771650
- NSC-799337
- SB16880
- NCGC00386423-03
- NCGC00386423-04
- AC-32943
- AS-35164
- FA137648
- HY-16071
- F459624
- BRD-K32127727-001-01-8
- BRD-K32127727-001-02-6
- Z2685929061
- SCHEMBL850592
- BRD-A77091532-001-01-9
- DA-35320
- DB-323674
- SCHEMBL851075
- AKOS026750506
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