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TEZACAFTOR
SynDRA canonical compound SYN0038169 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | CFTR |
|---|
| Mechanism of action | CFTR channel agonist |
|---|
| Indication | cystic fibrosis |
|---|
| Disease area | pulmonary |
|---|
All known targets
Mechanisms of action (all sources)
- CFTR POSITIVE MODULATOR
- Cystic fibrosis transmembrane conductance regulator positive modulator
- CFTR MODULATOR
- CFTR channel agonist
- CFTR BINDER
- CFTR PHARMACOLOGICAL CHAPERONE
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PDE4D
- ABCB11
- NR3C1
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MLNR
- NR1I2
- OPRD1
- ADORA1
- OPRM1
- PDE3A
- PGR
- PPARG
- PTGS2
- SCN5A
- SLC29A1
- SLC6A2
- SLC6A3
- HRH3
- HRH1
- HDAC6
- GHSR
- ADORA2A
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
- CCKAR
- CHRM1
ATC classes
- OTHER RESPIRATORY SYSTEM PRODUCTS
Cross-references
Synonyms
- ALYFTREK
- Alyftrek
- VX-661
- Tezacaftor component of symkevi
- Tezacaftor component of trikafta
- VX 661
- Tezacaftor (VX-661)
- Tezacaftor [USAN]
- VX661
- 8RW88Y506K
- UNII-8RW88Y506K
- CV6
- TEZACAFTOR [MI]
- TEZACAFTOR [INN]
- Tezacaftor (USAN/INN)
- TEZACAFTOR [WHO-DD]
- SCHEMBL322362
- VX 661;VX661;Tezacaftor
- CHEMBL3544914
- SCHEMBL10034144
- TEZACAFTOR [ORANGE BOOK]
- GTPL10199
- DTXSID40673070
- BDBM281054
- SYMKEVI COMPONENT TEZACAFTOR
- BCP07173
- EX-A1759
- TRIKAFTA COMPONENT TEZACAFTOR
- MFCD23106064
- s7059
- US10022352, Compound 315
- ZINC68206930
- CCG-269854
- CS-1078
- DB11712
- TEZACAFTOR COMPONENT OF TRIKAFTA
- AC-32773
- AS-35211
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