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MK-1064
SynDRA canonical compound SYN0038101 — structure-anchored drug synonym record
| Clinical phase | Phase 1 |
|---|
| Primary target(s) | HCRTR2 |
|---|
| Mechanism of action | orexin receptor antagonist |
|---|
All known targets
Mechanisms of action (all sources)
- HCRTR1 ANTAGONIST
- HCRTR2 ANTAGONIST
- orexin receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR2A
- CYP3A4
- ADGRF1
- NEIL2
- HTR1A
- HTR1B
- HTR1D
- HTR1E
- HTR2B
- HTR6
- MBD4
- MPG
- MUTYH
- NEIL1
- OGG1
- HRH3
- OPRD1
- OPRK1
- OPRM1
- S1PR1
- SIGMAR1
- SLC6A2
- SLC6A3
- SLC6A4
- SMUG1
- TDG
- TMEM97
- TSPO
- HRH4
- HRH2
- ADRA1A
- CHRM2
- ADRA1B
- ADRA1D
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Cross-references
Synonyms
- MK 1064
- O812716S9E
- UNII-O812716S9E
- RefChem:159185
- MK1064
- CKTWQGHVNRYNCM-UHFFFAOYSA-N
- MFCD28502027
- C24H20ClN5O3
- GTPL9306
- orb1303845
- SCHEMBL3486358
- SCHEMBL30593431
- GLXC-10213
- MK-1064(Urokinase inhibitor 1)
- EX-A1222
- HYB25308
- BDBM50028059
- s6726
- AKOS030632030
- CS-5968
- SB16800
- NCGC00510490-03
- AC-36061
- AS-74199
- DA-65498
- HY-19914
- MK-1064?
- T3722
- D84025
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