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GILTERITINIB
SynDRA canonical compound SYN0038050 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | FLT3 |
|---|
| Mechanism of action | FLT3 inhibitor |
|---|
All known targets
- FLT3
- AXL
- ROS1
- LTK
- RET
- NTRK1
- MERTK
- ALK
- PHKG2
- MAPK9
- RAN
- RABL3
Mechanisms of action (all sources)
- FLT3 INHIBITOR
- Tyrosine-protein kinase receptor FLT3 inhibitor
- AXL INHIBITOR
- Tyrosine-protein kinase receptor UFO inhibitor
- ALK INHIBITOR
- ROS1 INHIBITOR
- LTK INHIBITOR
- MERTK INHIBITOR
- NTRK1 INHIBITOR
- RET INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- YJ005
- CDK2
- PDE4A
- PRKCI
- NUAK2
- OPA1
- OPRM1
- PAK4
- PDE3A
- PDXK
- PFKP
- PGR
- PGRMC1
- PIM1
- PIP4K2A
- PIP4K2C
- PKMYT1
- PKN1
- PKN2
- PRKAA1
- PRKACA
- PRKACB
- PRKACG
- PRKAG1
- PRKAG2
- PRKAR2A
- PRKCB
- NLK
- NEK9
- NEK1
- MAPKAPK5
- MAP3K20
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAPK1
- MAPK11
- MAPK14
- MAPK3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ALAT2
- CCNE1
- COMT
- EML4
- ETV6
- GAMT
- GNMT
- HNMT
- KSYK
- NNMT
- NSD2
- NTM1A
- NTMT1
- PNMT
Drug classes
- Tyrosine Kinase Inhibitors
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- XOSPATA
- Xospata
- gilteritinib fumarate
- xospata
- ASP2215
- ASP-2215
- UNII-66D92MGC8M
- 66D92MGC8M
- Gilteritinib [USAN:INN]
- Gilteritinib(ASP2215)
- Gilteritinib (USAN/INN)
- Gilteritinib (ASP2215)
- Gilteritinib (ASP-2215)
- SCHEMBL282229
- GTPL8708
- MolPort-038-934-933
- BDBM144315
- C29H44N8O3
- 3694AH
- s7754
- AKOS030234455
- ZINC113476229
- DB12141
- CS-3885
- KS-0000064E
- AS-35199
- ASP 2215
- Gilteritinib HCl
- gilteritinibum
- C6F
- GILTERITINIB [MI]
- GILTERITINIB [INN]
- GILTERITINIB [USAN]
- GILTERITINIB [WHO-DD]
- CHEMBL3301622
- CHEBI:145372
- DTXSID701027949
- BCP28756
Reported adverse events
- Alanine aminotransferase increased
- Aspartate aminotransferase increased
- Constipation
- Cough
- Dizziness
- Fatigue
- Myalgia
- Nausea
- Posterior reversible encephalopathy syndrome
- Abdominal pain
- Febrile neutropenia
- Headache
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