← SynDRA
ABEMACICLIB
SynDRA canonical compound SYN0038040 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CDK4 | CDK6 |
|---|
| Mechanism of action | CDK inhibitor |
|---|
| Indication | breast cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- CDK4
- CDK6
- GSK3B
- IRAK1
- KCNH2
- MAP4K4
- MAPK8
- PIM1
- PRKCA
- AAK1
- GAK
- PRKCB
Mechanisms of action (all sources)
- CDK4/6 inhibitor
- Cyclin-dependent kinase 4 inhibitor
- Cyclin-dependent kinase 6 inhibitor
- cyclin-dependent kinase inhibitor
- CDK4 MODULATOR
- CDK6 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DYRK4
- PIM2
- HIPK2
- HRH3
- HIPK1
- NTRK1
- CAMK2B
- PDE4D
- CAMK1
- CLK2
- STK17A
- CLK3
- BRAF
- ROS1
- FLT3
- SYK
- CSNK2A1
- CDK5
- YJ005
- MAPK10
- DYRK1B
- DYRK2
- DYRK3
- EGFR
- PRKACG
- PDPK1
- PRKACA
- PDGFRB
- PRKACB
- PDGFRA
- PDE3A
- PFKL
- PCYT1A
- PRKAG1
- PASK
- PAK6
- PAK4
- PAK3
- PRKAG2
- PDXK
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CCNA2
- HLAB
- PNMT
- NTMT1
- NTM1A
- NSD2
- NNMT
- MNAT1
- KSYK
- IFNG
- IFNB1
- HNMT
- GNMT
- CCNB1
- GAMT
- COMT
- CDK5R1
- CCNT1
- CCNK
- CCNH
- CCNE1
- CCND3
- CCND2
- CCND1
- TP53
Drug classes
- Kinase Inhibitors
- Kinase Inhibitor
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- VERZENIO
- Verzenio
- LY2835219
- verzenio
- LY-2835219
- ABEMACICLIB (LY2835219)
- CDK4/6 DUAL INHIBITOR
- LY-28352192-PYRIMIDINAMINE
- LY2835219 FREE BASE
- Verzenios
- UNII-60UAB198HK
- LY2835219 (free base);
- LY2835219 free base
- LY 2835219
- Abemaciclib (ly2835219)
- 60UAB198HK
- HY-16297A
- LY2835219 free base (Abemaciclib)
- CS-1230
- LY2835219 (free base)
- Abemaciclib [USAN:INN]
- rimidin-2-amine
- Verzenio (TN)
- 6ZV
- CDK4/6 dual inhibitor
- LY2835210
- ABEMACICLIB [MI]
- ABEMACICLIB [INN]
- ABEMACICLIB [JAN]
- Abemaciclib (JAN/USAN)
- ABEMACICLIB [USAN]
- ABEMACICLIB [WHO-DD]
- GTPL7382
- SCHEMBL2487229
- CHEMBL3301610
- ABEMACICLIB [ORANGE BOOK]
- DTXSID20673119
- EX-A521
Reported adverse events
- Alanine aminotransferase increased
- Alopecia
- Aspartate aminotransferase increased
- Dizziness
- Dysgeusia
- Dyspepsia
- Fatigue
- Headache
- Infection
- Lacrimation increased
- Nail disorder
- Nausea
Look up ABEMACICLIB in the interactive SynDRA portal →