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VACTOSERTIB
SynDRA canonical compound SYN0038007 — structure-anchored drug synonym record
| Clinical phase | Phase 2 |
|---|
| Primary target(s) | ACVR1B | TGFBR1 |
|---|
| Mechanism of action | TGF beta receptor inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- TGFBR1 INHIBITOR
- TGF-beta receptor type I inhibitor
- ACVR1B INHIBITOR
- TGF beta receptor inhibitor
- TGFBR1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- MAPK14
- TGFB1
- RIPK2
- KDR
- ABL1
- NEIL2
- MAPK1
- MBD4
- MINK1
- MUTYH
- NEIL1
- NTRK3
- NTHL1
- OGG1
- PDGFRA
- SMUG1
- TDG
- TGFBR2
- TRIM24
- MAP4K4
- KCNH2
- ACVR1
- HDAC6
- ACVRL1
- AURKA
- BMPR1A
- BMPR1B
- BRD4
- BRPF1
- CDK2
- CSNK1D
- CYP1A2
- CYP2C19
- CYP2C9
- CYP2D6
- CYP3A4
- FGFR3
- FLT1
- FLT4
- GSK3B
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACV1B
- CP2C9
- CP2D6
- CP3A7
- KSYK
- SYK
Drug classes
- Protein Kinase Inhibitors
Cross-references
Synonyms
- Ew-7197
- TEW-7197
- EW 7197
- TEW 7197
- EW7197
- 6T4O391P5Y
- TEW7197
- vactosertibum
- RefChem:193482
- TGFBR1 Inhibitor TEW-7197
- DTXCID201436600
- MFCD28348363
- NOV-1301
- C22H18FN7
- VACTOSERTIB [INN]
- Vactosertib (TEW-7197)
- VACTOSERTIB [WHO-DD]
- SCHEMBL250076
- UNII-6T4O391P5Y
- GTPL8107
- orb1300718
- SCHEMBL26345807
- SCHEMBL29352498
- SCHEMBL29493095
- SCHEMBL29508696
- SCHEMBL30568127
- NOV1301
- GLXC-90505
- HMS3674I03
- EX-A1738
- BDBM50015639
- NSC854208
- s7530
- AKOS027250746
- CCG-264709
- CS-5679
- NSC-854208
- SB17272
- NCGC00386413-01
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