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CAPMATINIB
SynDRA canonical compound SYN0037968 — structure-anchored drug synonym record
| Clinical phase | Phase 3 |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | MET |
|---|
| Mechanism of action | c-Met inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- MET INHIBITOR
- Hepatocyte growth factor receptor inhibitor
- MET MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SYK
- AAK1
- NEK2
- PDXK
- PDGFRB
- PAK6
- PAK4
- PAK2
- PAICS
- OPA1
- OLA1
- NUAK2
- NTRK1
- NQO2
- NLK
- NEK9
- NEK7
- PEBP1
- PHKG2
- PIM1
- PRKAA1
- PRKAR2A
- PRKAG2
- PRKAG1
- PRKACG
- PRKACB
- PRKACA
- PLK4
- PIM2
- PKN3
- PKN2
- PKN1
- PKMYT1
- PIP4K2C
- PIP4K2A
- NEK3
- NEK1
- PRKCB
- MAPK11
- MAPK9
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Kinase Inhibitor
- Cytochrome P450 1A2 Inhibitors
- P-Glycoprotein Inhibitors
- Breast Cancer Resistance Protein Inhibitors
- Multidrug and Toxin Extrusion Transporter 1 Inhibitors
- Mesenchymal Epithelial Transition Inhibitors
- Multidrug and Toxin Extrusion Transporter 2 K Inhibitors
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- TABRECTA
- Tabrecta
- capmatinib hydrochloride
- capmatinib hydrochloride hydrate
- tabrecta
- NVP-INC280-NX
- INC280
- INCB-028060
- vcapmatinib dihydrochloride monohydrate
- INCB-28060
- CAPMATINIB (INCB28060)
- INC-280
- INCB-28060 FREE BASE
- INCB-28060A-1419
- INCB28060
- NVP-INC280
- NYP-INC280-NX
- UNII-TY34L4F9OZ
- INC28060
- INCB 28060
- INCB28060(Capmatinib)
- TY34L4F9OZ
- Capmatinib (INCB28060)
- C23H17FN6O
- INC.280
- Capmatinib [USAN]
- Capmatinib(INCB28060)
- Capmatinib [INN]
- benzamide hcl
- CAPMATINIB [MI]
- Capmatinib (USAN/INN)
- Capmatinib [USAN:INN]
- CAPMATINIB [WHO-DD]
- MLS006010965
- GTPL7904
- SCHEMBL1426819
- CHEMBL3188267
- DTXSID90145595
Reported adverse events
- Constipation
- Cough
- Fatigue
- Hypersensitivity
- Nausea
- Pyrexia
- Rash
- Vomiting
- Weight decreased
- Decreased appetite
- Dizziness
- Hepatotoxicity
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