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BINIMETINIB
SynDRA canonical compound SYN0037963 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | IL1R2 | IL6R | MAP2K1 | MAP2K2 | TNFRSF1A |
|---|
| Mechanism of action | MEK inhibitor |
|---|
| Indication | melanoma |
|---|
| Disease area | oncology |
|---|
All known targets
- MAP2K1
- MAP2K2
- IL1R2
- IL6R
- NQO2
- TNFRSF1A
Mechanisms of action (all sources)
- MAP2K1 INHIBITOR
- Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
- MAP2K2 INHIBITOR
- Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
- MAP2K1 NEGATIVE ALLOSTERIC MODULATOR
- MAP2K2 NEGATIVE ALLOSTERIC MODULATOR
- MEK inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SYK
- AAK1
- MYLK3
- PASK
- PAK4
- PAK2
- PAICS
- OPRM1
- OPRD1
- OPA1
- OLA1
- NUAK2
- NTRK1
- NR3C1
- NR1I2
- NLK
- NEK9
- NEK3
- NEK2
- NEK1
- NDUFA13
- PCYT1A
- PDE3A
- PDE4D
- PIP4K2C
- PRKAA1
- PPARG
- PLK4
- PLK1
- PKN3
- PKN2
- PKN1
- PKMYT1
- PIP4K2A
- PDGFRB
- PIM2
- PIM1
- PHKG2
- PGRMC1
- PGR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- MEKTOVI
- Mektovi
- mektovi
- MEK162
- ARRY-162
- ARRY-438162
- MEK-162
- NVP-MEK162
- ARRY 162
- MEK 162
- ARRY 438162
- UNII-181R97MR71
- Binimetinib (MEK162, ARRY-162, ARRY-438162)
- 181R97MR71
- MEK162 (ARRY-162, ARRY-438162)
- Binimetinib [USAN:INN]
- MEK162(Binimetinib)
- Binimetinib (JAN/USAN)
- NVP-ME
- Binimetinib (MEK-162)
- MFCD22124525
- binimetinibum
- Mektovi (TN)
- ARRY-162; ARRY-438162; MEK 162; ARRY 162; ARRY 438162
- Binimetinib; Mek162
- BINIMETINIB [MI]
- Binimetinib (MEK162)
- BINIMETINIB [INN]
- BINIMETINIB [JAN]
- BINIMETINIB [USAN]
- BINIMETINIB [WHO-DD]
- MLS006011180
- SCHEMBL570088
- GTPL7921
- CHEMBL3187723
- AMY9056
- BINIMETINIB [ORANGE BOOK]
- DTXSID70209422
Reported adverse events
- Abdominal pain
- Alopecia
- Colitis
- Constipation
- Dizziness
- Dry skin
- Dysgeusia
- Erythema
- Fatigue
- Headache
- Hyperkeratosis
- Hypertension
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