← SynDRA

UPROSERTIB

SynDRA canonical compound SYN0037866 — structure-anchored drug synonym record

All known targets

• AKT3
• AKT1
• AKT2

Mechanisms of action (all sources)

• AKT2 INHIBITOR
• Serine/threonine-protein kinase AKT inhibitor
• AKT3 INHIBITOR
• AKT1 INHIBITOR
• AKT3 MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• PRKCD
• PRKACB
• SGK1
• PRKCB
• RPS6KB1
• CDK16
• CSNK1A1
• RPS6KA1
• ROCK2
• ROCK1
• LATS1
• SYK
• PKN1
• PRKACA
• CDK7
• PRKCI
• MELK
• PRKD2
• PRKD3
• PRKCA
• DYRK1A
• MARK3
• MARK2
• PRKACG
• PIK3CA
• PEBP1
• PFKP
• PGRMC1
• PHKG2
• PRKAR2A
• PRKAG2
• PIM1
• PRKAA1
• PIM2
• PRKAG1
• PIP4K2A
• PIP4K2C
• PDXK
• PKN2
• PLK4

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• IFNG
• KSYK
• NSD2
• PRKCE
• PRKCG
• PRKCH
• PRKCQ
• PRKCZ
• PRKD1

Cross-references

• PubChem CID: 51042438
• ChEMBL: CHEMBL3137336
• DrugBank: DB11969
• KEGG: D10674
• TTD: D01NEC

Synonyms

• Akt inhibitor gsk-2141795
• Akt inhibitor gsk2141795
• Gsk-2141795
• GSK-2141795C
• GSK2141795
• GSK2141795C
• UNII-ZXM835LQ5E
• Uprosertib (GSK2141795)
• ZXM835LQ5E
• GSK795
• GSK-2141795
• 2-Furancarboxamide, N-[(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-;2-Furancarboxamide, N-[(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-
• Uprosertib [USAN:INN]
• Uprosertib (USAN/INN)
• Uprosertib, GSK2141795
• SCHEMBL168584
• GTPL7902
• CHEMBL3137336
• MolPort-044-560-307
• AXTAPYRUEKNRBA-JTQLQIEISA-N
• N-((S)-1-Amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide
• 2-Furancarboxamide, N-((1S)-2-amino-1-((3,4-difluorophenyl)methyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-
• N-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide
• N-((1S)-1-(Aminomethyl)-2-(3,4-difluorophenyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide
• N-[(1S)-1-(Aminomethyl)-2-(3,4-difluorophenyl)ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide
• Uprosertib [USAN]
• UPROSERTIB [INN]
• UPROSERTIB [WHO-DD]
• BCP28204
• EX-A1593
• BDBM50170284
• MFCD28144686
• NSC778368
• NSC800960
• s7492
• ZINC43197676
• AKOS027323909
• CCG-268992
• DB11969