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VENETOCLAX
SynDRA canonical compound SYN0037841 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | BCL2 |
|---|
| Mechanism of action | BCL inhibitor |
|---|
| Indication | chronic lymphocytic leukemia (CLL) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- BCL2
- BCL2L1
- BCL2L2
- ASPH
- BAD
- MCL1
Mechanisms of action (all sources)
- BCL2 inhibitor
- Apoptosis regulator Bcl-2 inhibitor
- BCL2 ANTAGONIST
- BCL2L1 ANTAGONIST
- BCL2L2 ANTAGONIST
- MCL1 ANTAGONIST
- BCL inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA3
- NSD1
- NSD2
- CYP2C9
- NSD3
- MAOA
- MAPK1
- MC3R
- NR1I2
- ABL1
- PDE3A
- PDE4D
- PGR
- PTGS2
- SLC6A2
- SLC6A3
- SLC6A4
- OPRD1
- HRH1
- KCNH2
- GSK3B
- FLT3
- FGFR3
- DRD3
- DRD1
- CSNK1D
- CHRM1
- CDK2
- BRPF1
- BRD4
- BCL2A1
- AURKA
- ADRB2
- ADRA2C
- TRIM24
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- B2CL1
- B2CL2
- BID
- COMT
- GAMT
- GNMT
- GPX1
- GPX4
- HNMT
- IFNG
- KSYK
- NNMT
- PNMT
- SYK
Drug classes
- Antineoplastic Agents
- P-Glycoprotein Inhibitors
- BCL-2 Inhibitor
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- VENCLEXTA
- Venclexta
- venclyxto
- ABT-199
- venclexta
- GDC-0199
- ABT199
- ABBVIE
- C45H50CLN7O7S
- CHRONIC LYMPHOCYTIC LEUKAEMIA THERAPY
- RG-7601
- RG7601
- UNII-N54AIC43PW
- Venclyxto
- VENETOCLAX (ABT-199)
- ABT 199
- GDC 0199
- Venetoclax (ABT199)
- Venetoclax; Abt-199
- Venetoclax(ABT-199)
- Venetoclax (ABT-199)
- N54AIC43PW
- ABT-199 (GDC-0199)
- BDBM189459
- Venetoclax [USAN:INN]
- Venclexta (TN)
- VENETOCLAX [MI]
- VENETOCLAX [INN]
- VENETOCLAX [JAN]
- VENETOCLAX [USAN]
- VENETOCLAX [WHO-DD]
- MLS006010298
- SCHEMBL523816
- Venetoclax (JAN/USAN/INN)
- AMY343
- GTPL8318
- CHEMBL3137309
Reported adverse events
- Abdominal pain
- Arthralgia
- Blood creatinine increased
- Constipation
- Dizziness
- Fatigue
- Febrile neutropenia
- Headache
- Hypotension
- Infection
- Nausea
- Neutropenia
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