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OSILODROSTAT
SynDRA canonical compound SYN0037812 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | CYP11B1 | CYP11B2 |
|---|
| Mechanism of action | cytochrome P450 inhibitor |
|---|
All known targets
- CYP11B1
- CYP11B2
- CYP19A1
- Cyp11b1
- Cyp11b2
Mechanisms of action (all sources)
- CYP11B1 INHIBITOR
- Cytochrome P450 11B1 inhibitor
- CYP11B2 INHIBITOR
- cytochrome P450 inhibitor
- CYP11B1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HRH1
- CYP17A1
- ADORA1
- HRH3
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- HTR5A
- HTR6
- HTR7
- KCNH2
- MC3R
- MC4R
- MLNR
- NPY1R
- NPY2R
- NTSR1
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PDE6A
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- TACR1
- TACR2
- HRH2
- GHSR
- ADORA2A
- CHRM2
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Cytochrome P450 2D6 Inhibitors
- Cytochrome P450 1A2 Inhibitors
- Cytochrome P450 2C19 Inhibitors
- Cytochrome P450 3A4 Inhibitors
- Cytochrome P450 3A5 Inhibitors
- Cortisol Synthesis Inhibitor
- Cytochrome P450 11B1 Inhibitors
ATC classes
- H02C · ANTIADRENAL PREPARATIONS
Cross-references
Synonyms
- ISTURISA
- Isturisa
- osilodrostat phosphate
- LCI699-NX
- LCI-699
- isturisa
- Lci-699
- Lci699
- LCI-699-NX
- LCI699
- LCI 699
- UNII-5YL4IQ1078
- CHEMBL3099695
- 5YL4IQ1078
- Osilodrostat [USAN:INN]
- Osilodrostat (USAN/INN)
- GTPL8310
- SCHEMBL12460772
- DTXSID40156570
- MolPort-044-560-410
- EX-A1397
- ZINC72318114
- s7456
- BDBM50444549
- AKOS027323750
- DB11837
- CS-6896
- HY-16276
- KB-78108
- Z-3271
- D11061
- (+)-Osilodrostat
- osilodrostatum
- RefChem:56448
- DTXCID4079061
- H02CA02
- Osilodrostat (LCI699)
- Osilodrostat free base
Reported adverse events
- Blood testosterone increased
- Dizziness
- Fatigue
- Hypotension
- Myalgia
- Rash
- Tachycardia
- Vomiting
- Abdominal pain
- Adrenal insufficiency
- Arthralgia
- Back pain
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