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BIRINAPANT

SynDRA canonical compound SYN0037768 — structure-anchored drug synonym record

All known targets

• BIRC2
• XIAP
• BIRC3

Mechanisms of action (all sources)

• XIAP INHIBITOR
• BIRC3 INHIBITOR
• cIAP1/cIAP2 inhibitor
• BIRC2 INHIBITOR
• BIRC2 ANTAGONIST
• XIAP ANTAGONIST
• XIAP MODULATOR
• BIRC2 MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• BIRC7
• ABL1
• AURKA
• BRD4
• BRPF1
• CDK2
• CSNK1D
• FGFR3
• GSK3B
• MAPK1
• TRIM24

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• KSYK
• NSD2
• SYK

Cross-references

• PubChem CID: 49836020
• ChEMBL: CHEMBL3039522
• DrugBank: DB11782
• ChEBI: 177705
• KEGG: D10417
• PDB: GT6
• TTD: D0E8NP
• LINCS BRD: BRD-K71221037

Synonyms

• TL-32711
• TL32711
• Birinapant (TL32711)
• TL 32711
• UNII-6O4Z07B57R
• 6O4Z07B57R
• (2S)-N-[(2S)-1-[(2R,4S)-2-[[6-fluoro-2-[6-fluoro-3-[[(2R,4S)-4-hydroxy-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidin-2-yl]methyl]-1H-indol-2-yl]-1H-indol-3-yl]methyl]-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl]-2-(methylamino)propanamide
• Birinapant [USAN]
• (2S,2'S)-N,N'-((2S,2'S)-((3S,3'S,5R,5'R)-5,5'-((6,6'-difluoro-1H,1'H-[2,2'-biindole]-3,3'-diyl)bis(methylene))bis(3-hydroxypyrrolidine-5,1-diyl))bis(1-oxobutane-2,1-diyl))bis(2-(methylamino)propanamide)
• (2s,2's)-N,N'-[(6,6'-Difluoro-1h,1'h-2,2'-Biindole-3,3'-Diyl)bis{methanediyl[(2r,4s)-4-Hydroxypyrrolidine-2,1-Diyl][(2s)-1-Oxobutane-1,2-Diyl]}]bis[2-(Methylamino)propanamide]
• Birinapant [USAN:INN]
• Birinapant di-HCl
• PROPANAMIDE, N,N'-((6,6'-DIFLUORO(2,2'-BI-1H-INDOLE)-3,3'-DIYL)BIS(METHYLENE((2R,4S)-4-HYDROXY-2,1-PYRROLIDINEDIYL)((1S)-1-ETHYL-2-OXO-2,1-ETHANEDIYL)))BIS(2-(METHYLAMINO)-, (2S,2'S)-
• Propanamide, N,N'-[(6,6'-difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-, (2S,2'S)-
• BIRINAPANT [INN]
• Birinapant (USAN/INN)
• BIRINAPANT [WHO-DD]
• MLS006011237
• GTPL7432
• TL32711 2HCl
• CHEMBL3039522
• SCHEMBL10049847
• DTXSID30155057
• EX-A258
• TL-32711 2HCl
• CHEBI:177705
• BDBM50071920
• MFCD25976869
• NSC767128
• NSC816007
• s7015
• ZINC96941868
• AKOS030526366
• CCG-270498
• CS-1719
• DB11782
• NSC-767128
• NSC-816007