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CLOMIPHENE
SynDRA canonical compound SYN0037139 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ESR1 |
|---|
| Mechanism of action | Estrogen receptor antagonist |
|---|
| Indication | infertility |
|---|
| Disease area | obstetrics/gynecology |
|---|
All known targets
- ESR1
- ADORA3
- HTR6
- FYN
- HRH1
- HTR2A
- HTR2B
- HTR2C
- KCNH2
- ADRA2A
- PTGS1
- Pgrmc1
Mechanisms of action (all sources)
- ESR1 ANTAGONIST
- ESR1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- HTR1A
- PDE4A
- PGR
- DRD1
- ABCB1
- PPARD
- MAPT
- NFE2L2
- NFKB1
- NLRP3
- NPSR1
- NR1H4
- OPRM1
- PDE3A
- PLIN1
- PPARG
- MAOA
- RXRA
- SLCO1B1
- SLCO1B3
- SMAD3
- SMPD1
- SNCA
- TBXA2R
- TDP1
- THRB
- TP53
- UBE2N
- USP1
- MAPK1
- KDR
- LMNA
- DHCR24
- ACHE
- ADRA1A
- ATAD5
- ATXN2
- BAZ2B
- CBX1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- RARA
- PRGR
- PPP1CA
- PLIN5
- NR1I2
- MLLT3
- MDM4
- MDM2
- KCNQ1
- KCMB4
- KCMB2
- KCMB1
- IDHC
- GLI3
- GEMI
- ESRRA
- ESR2
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- CP19A
- APAF
- ANDR
- ADRB2
- TSHR
Drug classes
- Selective Estrogen Receptor Modulators
- Estrogen Antagonists
- Estrogen Receptor Modulators
- Fertility Agents, Female
- Hormone Antagonists
- Reproductive Control Agents
- Estrogen Agonist/Antagonist
ATC classes
- G03G · GONADOTROPINS AND OTHER OVULATION STIMULANTS
Cross-references
Synonyms
- CLOMID
- CLOMIPHENE CITRATE
- MILOPHENE
- Milophene
- SEROPHENE
- clomifene
- clomifene citrate
- Clomiphene B
- clomiphene citrate
- clomid
- Clomifene
- Clomifeno
- Androxal
- Chlomaphene
- Chloramifene
- Cisclomifenum
- Cisclomiphene
- Clomifen
- Clomifenum
- Clomifert
- Clostilbegit
- Enclomifene
- Enclomifeno
- Enclomifenum
- Enclomiphen
- Enclomiphene
- Klostilbegit
- Transclomifenum
- Transclomiphene
- Zuclomifene
- Zuclomifeno
- Zuclomifenum
- Zuclomiphene
- Clomiphene B;Enclomiphene [USAN]
- ISOMER B
- Zuclomiphene [USAN]
- Cis-Clomifene
- Cis-Clomiphene
Reported adverse events
- Acne
- Acute abdomen
- Anxiety
- Arrhythmia
- Arthralgia
- Endometriosis
- Headache
- Leukocytosis
- Nausea
- Vomiting
- Transaminases increased
- Migraine
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