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PIRARUBICIN
SynDRA canonical compound SYN0037137 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | TOP2A |
|---|
| Mechanism of action | Topoisomerase inhibitor |
|---|
| Indication | breast cancer |
|---|
| Disease area | oncology |
|---|
All known targets
Mechanisms of action (all sources)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- HDAC6
- PTGS1
- POLK
- KMT2A
- MAOA
- OPRM1
- PDE3A
- PDE4A
- PGR
- POLI
- ACHE
- KAT2A
- SLC6A2
- SLC6A3
- SLC6A4
- SMAD3
- SNCA
- TBXA2R
- TDP1
- KCNH2
- HTT
- ADORA1
- HTR2B
- ADRA1A
- ADRA2A
- AR
- BLM
- CHRM1
- CHRM2
- DRD1
- DRD3
- EYA2
- F2
- FAP
- FEN1
- GLS
- HRH3
- HTR1A
- USP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- HDAC9
- TP53
- TOR1A
- SYK
- PRGR
- PPARD
- PARP1
- NSD2
- NR1H4
- NF2L2
- MUS81
- KSYK
- JUN
- IFNB1
- HLAB
- GLSK
- ALAT2
- GLI3
- GCR
- ESRRA
- ECE1
- CTBP1
- CREB1
- CP3A7
- CP3A4
- CP2C9
- CASP7
- CASP3
- ATXN2
- ATAD5
- ANDR
- UBP1
Drug classes
ATC classes
- L01D · CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
Cross-references
Synonyms
- pinorubicin
- therarubicin
- Pirarubicine
- Pirarubicina
- Adriamycin, tetrahydropyranyl
- Theprubicin
- Thp-adm
- Pinorubicin (TN)
- Therarubucin (TN)
- MFCD00869742
- C32H37NO12
- Therarubicin (TN)
- NCGC00167982-01
- Pirarubicin(THP)?
- Pirarubicin (JP17/INN)
- SCHEMBL15472856
- CHEBI:32011
- EX-A494
- KMSKQZKKOZQFFG-HSUXVGOQSA-N
- GLXC-06538
- AKOS015895621
- FP27079
- NCGC00167982-02
- NCGC00167982-04
- NCGC00167982-06
- NCGC00167982-09
- D01885
- THP-ADM
- Pirarubicinum
- THP-adriamycin
- THP-doxorubicin
- 4'-O-Tetrahydropyranyladriamycin
- Pinorubicin
- 4'-O-Tetrahydropyranyldoxorubicin
- D58G680W0G
- DTXCID0026755
- thepirubicin
- Tepirubicin
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