← SynDRA

OLVEREMBATINIB

SynDRA canonical compound SYN0036650 — structure-anchored drug synonym record

All known targets

• ABL1
• BCR
• BCR-ABL1

Mechanisms of action (all sources)

• ABL1 INHIBITOR
• BCR INHIBITOR
• Bcr-Abl kinase inhibitor

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• HDAC6
• CYP2C19
• CYP2C9
• FGFR1
• FLT3
• PDGFRA
• LRRK2
• KIT
• TEK
• SRC
• RET
• PDGFRB
• BRAF
• KCNH2
• CYP1A2
• DDR1
• CYP3A4
• CYP2E1
• CYP2D6
• TIE1

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP2C9
• CP2D6
• HLAB
• IFNB1
• IFNG
• IP6K1
• NSD2

Cross-references

• PubChem CID: 51038269
• ChEMBL: CHEMBL2316582
• DrugBank: DB16185
• KEGG: D12175
• PDB: T3X
• Wikipedia: Olverembatinib
• TTD: DH5RN1
• LINCS BRD: BRD-K35329391

Synonyms

• HQP1351
• Olverembatinib dimesylate
• D-824
• D-824 DIMESYLATE
• GZD-824
• GZD-824 DIMESYLATE
• HQP-1351
• HQP-1351 DIMESYLATE
• HQP1351 DIMESYLATE
• GZD824
• 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
• UNII-KV1M7Q3CBP
• KV1M7Q3CBP
• 4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide
• CHEMBL2316582
• Benzamide, 4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-
• 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-(2-{1H-pyrazolo[3,4-b]pyridin-5-yl}ethynyl)benzamide
• Benzamide, 4-methyl-N-(4-((4-methyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(1H-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)-
• HQP1351 free base
• HQP-1351 free base
• SCHEMBL3424528
• GTPL10630
• EX-A829
• AOB87323
• BCP07502
• BDBM50425780
• ZINC95594040
• AKOS026750647
• CS-1444
• SB16617
• compound 10a [PMID: 23301703]
• NCGC00351607-06
• AK547162
• AS-75170
• HY-15666
• FT-0700150
• A16264
• W-6136