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IDELALISIB
SynDRA canonical compound SYN0034405 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | PIK3CG |
|---|
| Mechanism of action | PI3K inhibitor |
|---|
| Indication | chronic lymphocytic leukemia (CLL) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- PIK3CD
- PIK3CG
- PIK3CA
- PIK3CB
- CCL3
- CCL4
- PIK3C3
- PRKDC
- Pik3cg
Mechanisms of action (all sources)
- PI3K inhibitor
- PIK3CD INHIBITOR
- PI3-kinase p110-delta subunit inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR1A
- SYK
- PTGS1
- SLC6A3
- AAK1
- PDE3A
- PDE4A
- PDE4D
- PDGFRA
- PASK
- PDGFRB
- PDPK1
- PDXK
- PEAK1
- PEBP1
- PFKP
- PBK
- PAK5
- PAK6
- PGRMC1
- PAK4
- PAK3
- PAK2
- PAK1
- PAICS
- OXSR1
- OPRM1
- OPA1
- NUAK2
- NUAK1
- NTRK3
- PGR
- PHKG1
- NTRK1
- PHKG2
- PRKCA
- PRKAR2A
- PRKAG2
- PRKAG1
- PRKACG
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- KSYK
- NSD2
- PIK3R1
- PIK3R2
- PK3CA
- PK3CB
- PK3CG
Drug classes
- Kinase Inhibitors
- Antineoplastic Agents
- Enzyme Inhibitors
- Kinase Inhibitor
- Cytochrome P450 3A Inhibitors
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- ZYDELIG
- Zydelig
- CAL-101
- zydelig
- GS-1101
- GS-11CAL-101
- CAL-101 (GS-1101)
- IDELALISIBCT-CAL101IDEALISIBCAL-101CAL 101GS-1101GS 1101ZYDELIGA-1138CAL101
- CAL 101
- CAL101
- UNII-YG57I8T5M0
- CAL-101 (Idelalisib, GS-1101)
- YG57I8T5M0
- CHEMBL2216870
- CHEBI:82701
- AK145603
- GS 1101
- Idelalisib (CAL-101)
- Idelalisib; CAL-101
- Idelalisib [INN]
- Idelalisib [USAN:INN]
- Idealisib
- Zydelig (TN)
- IDELALISIB [MI]
- IDELALISIB [JAN]
- IDELALISIB [USAN]
- IDELALISIB [VANDF]
- IDELALISIB [WHO-DD]
- MLS006010985
- Idelalisib (JAN/USAN/INN)
- SCHEMBL356400
- GTPL6741
- IDELALISIB [ORANGE BOOK]
- SCHEMBL16782604
- HSDB 8408
- AMY9239
- CAL-101/CAL101
Reported adverse events
- Infection
- Neutropenia
- Pneumonitis
- Rash
- Abdominal pain
- Colitis
- Hepatotoxicity
- Hypersensitivity
- Lymphoma
- Pneumonia
- Sepsis
- Stevens-Johnson syndrome
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