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COBIMETINIB
SynDRA canonical compound SYN0033857 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | MAP2K1 |
|---|
| Mechanism of action | MEK inhibitor |
|---|
| Indication | melanoma |
|---|
| Disease area | oncology |
|---|
All known targets
- MAP2K1
- MAP2K2
- ACTR3
- BRAF
- KCNH2
- MAP2K7
Mechanisms of action (all sources)
- MAP2K1 INHIBITOR
- Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
- MAP2K2 INHIBITOR
- Dual specificity mitogen-activated protein kinase kinase 2 inhibitor
- MAP2K1 NEGATIVE ALLOSTERIC MODULATOR
- MAP2K2 NEGATIVE ALLOSTERIC MODULATOR
- MAP2K7 NEGATIVE ALLOSTERIC MODULATOR
- MEK inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRM1
- SLC6A4
- SLC6A3
- SYK
- PDK1
- PIK3CA
- PHKG2
- PGRMC1
- PGR
- PFKP
- PEBP1
- PDXK
- PDGFRB
- PIK3CG
- PDGFRA
- PDE4A
- PDE3A
- PCYT1A
- PASK
- PAK6
- PAK4
- PIK3CB
- PIM1
- PAICS
- PIM2
- PRKCB
- PRKCA
- PRKAR2A
- PRKAG2
- PRKAG1
- PRKACG
- PRKACB
- PRKACA
- PRKAA1
- PLK4
- PLK3
- PLK1
- PKN3
- PKN2
- PKN1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- KSYK
- MP2K7
- NSD2
- NTM1A
- NTMT1
Drug classes
- Kinase Inhibitors
- Kinase Inhibitor
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- COTELLIC
- Cotellic
- RG 7420
- GDC-0973
- cobimetinib butyrate
- cobimetinib fumarate
- cotellic
- XL518
- cobimetinib hemifumarate
- Gdc-0623
- Xl 518
- Xl518
- RG-7420
- RG7420
- Cobimetinib fumarate
- Cobimetinib hemifumarate
- Xl-518 hemifumarate
- GDC-0973 hemifumarate
- UNII-6EXI96H8SV
- 6EXI96H8SV
- Cobimetinib fumarate [USAN]
- Cobimetinib fumarate (USAN)
- Cotellic (TN)
- CHEMBL2364607
- CHEBI:90853
- D10615
- GDC 0623
- UNII-HW67545I4Q
- RG 7421
- GDC0623
- HW67545I4Q
- G-868
- RFWVETIZUQEJEF-UHFFFAOYSA-N
- GTPL9909
- SCHEMBL1615104
- CHEMBL3330650
- MolPort-039-193-834
- BCP28689
Reported adverse events
- Chills
- Dry skin
- Fatigue
- Hypertension
- Nausea
- Pneumonitis
- Pruritus
- Pyrexia
- Rhabdomyolysis
- Stomatitis
- Vomiting
- Acne
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