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IXAZOMIB
SynDRA canonical compound SYN0033799 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | PSMB1 |
|---|
| Mechanism of action | Proteasome inhibitor |
|---|
| Indication | multiple myeloma |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- PSMB1
- PSMB5
- PSMB2
- PSMD13
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- ADRM1
- PSMC2
Mechanisms of action (all sources)
- proteasome inhibitor
- PSMD1 INHIBITOR
- PSMB2 INHIBITOR
- PSMB1 INHIBITOR
- PSMB5 INHIBITOR
- PSMB8 INHIBITOR
- PSMB9 INHIBITOR
- PSMB6 INHIBITOR
- PSMD14 INHIBITOR
- PSMA1 INHIBITOR
- PSMA2 INHIBITOR
- PSMA3 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- ADORA3
- SLC6A4
- SLC6A3
- SLC6A2
- PTGS1
- PGR
- PDE4A
- PDE3A
- OPRM1
- MAOA
- KDR
- KCNH2
- HTR2B
- HTR1A
- HRH3
- HDAC6
- F2
- ESR1
- ENGASE
- DRD3
- DRD1
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATXN2
- HLAB
- IFNB1
- IFNG
- KSYK
- MITF
- NFKB1
- NFKB2
- NSD2
- RELA
- SNCA
- SYK
- SYUA
- TFE3
- TP53
Drug classes
- Proteasome Inhibitors
- Antineoplastic Agents
- Enzyme Inhibitors
- Protease Inhibitors
- Proteasome Inhibitor
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- NINLARO
- Ninlaro
- ixazomib citrate
- MLN2238
- MLN9708
- ninlaro
- MLN-2238
- MLN-9708 FREE BASE
- MLN 2238
- Ixazomib [INN]
- Ixazomib(MLN2238)
- Ixazomib (MLN2238)
- CHEMBL2141296
- Ixazomib (USAN)
- IXAZOMIB [USAN]
- 71050168A2
- Ixazomib [USAN:INN]
- Ixozamib
- Ixazomib Impurity
- UNII-71050168A2
- MLN2238(Ixazomib)
- IXAZOMIB [MI]
- IXAZOMIB [WHO-DD]
- Ixazomib (MLN-2238)
- GTPL8450
- SCHEMBL3742758
- CHEBI:90942
- EX-A547
- DTXSID701025662
- AMY19380
- BCP02410
- BCP24078
- BDBM50398609
- MFCD18251438
- NSC766907
- s2180
- AKOS015995120
- ZINC169946773
Reported adverse events
- Angioedema
- Bronchitis
- Constipation
- Eye disorder
- Herpes zoster
- Nausea
- Neutropenia
- Rash
- Thrombocytopenia
- Toxic epidermal necrolysis
- Upper respiratory tract infection
- Vomiting
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