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AV-412 FREE BASE
SynDRA canonical compound SYN0033794 — structure-anchored drug synonym record
| Clinical phase | Phase 1 |
|---|
| Primary target(s) | ERBB2 |
|---|
| Mechanism of action | Receptor tyrosine protein kinase inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- Receptor tyrosine protein kinase inhibitor
- EGFR INHIBITOR
- Epidermal growth factor receptor erbB1 inhibitor
- ERBB2 INHIBITOR
- Receptor protein-tyrosine kinase erbB-2 inhibitor
- tyrosine kinase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SLK
- STK10
- TEC
- SYK
- BTK
- MAP3K1
- YES1
- OLA1
- OPA1
- NUAK2
- PAICS
- PGRMC1
- PAK2
- NTRK1
- PAK4
- PAK6
- PASK
- PDGFRB
- PDXK
- NQO2
- PFKP
- AAK1
- PHKG2
- NLK
- PRKAR2A
- PRKAG2
- PRKAG1
- PRKACG
- PRKACB
- PRKACA
- PRKAA1
- PLK4
- PKN3
- PKN2
- PKN1
- PKMYT1
- PIP4K2C
- PIP4K2A
- PIM2
- PIM1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- HLAB
- IFNB1
- IFNG
- KSYK
- MITF
- NSD2
- TFE3
Cross-references
Synonyms
- AV-412
- UNII-41OXH4FE7B
- MP-312
- RefChem:115727
- DTXCID80118894
- MP 412
- AV-412 (free base)
- MFCD16038939
- AV-412(MP-412)
- C27H28ClFN6O
- HMS3244M15
- MP-412 free base
- orb1678998
- SCHEMBL1818495
- SCHEMBL29479075
- SCHEMBL29944737
- AV-412 free base;MP-412
- EX-A755
- GLXC-07053
- HMS3244M16
- HMS3244N15
- BDBM50468245
- HY-10346A
- NSC799340
- TQ0293
- AKOS027251058
- NSC-799340
- NCGC00263195-01
- NCGC00263195-03
- NCGC00263195-04
- AC-36037
- AS-16187
- NS00071666
- BRD-K23190681-001-01-1
- C41H44ClFN6O7S2
- MP 412 [WHO-DD]
- EX-A756
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