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PIMAVANSERIN
SynDRA canonical compound SYN0033695 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | HTR2A |
|---|
| Mechanism of action | Serotonin receptor inverse agonist |
|---|
| Indication | Parkinson's Disease |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
Mechanisms of action (all sources)
- Serotonin receptor inverse agonist
- HTR2A INVERSE AGONIST
- Serotonin 2a (5-HT2a) receptor inverse agonist
- HTR2A AGONIST
- HTR2C AGONIST
- HTR2A MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- GPR35
- HTR2B
- DRD1
- GPR65
- CX3CR1
- CHRM2
- DRD3
- KCNH2
- APLNR
- ADRB2
- SLC6A2
- GPR183
- NEIL1
- KDR
- HTR1A
- HRH3
- HDAC6
- MAOA
- ABCB1
- NEIL2
- OGG1
- PDE3A
- PDE4A
- PGR
- PTGS1
- S1PR1
- SLC6A3
- SLC6A4
- TBXA2R
- OPRM1
- GLP1R
- GPR119
- CHRM1
- ACHE
- ADGRF1
- ADORA3
- ADRA1A
- ADRA2A
- AGTR1
- AR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2D6
- HRH1
- KSYK
- NCF1
- NSD2
- SYK
Drug classes
- Atypical Antipsychotic
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Neurotransmitter Agents
- Psychotropic Drugs
- Serotonin 5-HT2 Receptor Antagonists
- Serotonin Agents
- Serotonin Antagonists
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- NUPLAZID
- Nuplazid
- pimavanserin tartrate
- ACP-103
- nuplazid
- Pimavanserine
- Pimavanserina
- ST51054136
- AC-5273
- I14-1981
- Pimavanserin tartrate
- UNII-NA83F1SJSR
- 706782-28-7 (tartrate)
- NA83F1SJSR
- Pimavanserin tartrate [USAN]
- Pimavanserin tartrate (USAN)
- Nuplazide (TN)
- pimavanserin hemitartrate
- DTXSID50220958
- CHEBI:133014
- HMS3886L06
- HY-14557A
- AKOS027327334
- CCG-270608
- CS-7954
- AC-29901
- AS-56699
- D08969
- Q27284759
- JZ963P0DIK
- Pimavanserin Tartrate
- ACP 103
- pimavanserina
- pimavanserine
- CHEBI:133017
- pimavanserinum
- RefChem:59074
Reported adverse events
- Confusional state
- Constipation
- Gait disturbance
- Gastrointestinal disorder
- Hallucination
- Nausea
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