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VINFLUNINE
SynDRA canonical compound SYN0033398 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Mechanism of action | microtubule inhibitor |
|---|
| Indication | bladder cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- TUBB
- TUBB1
- TUBB2A
- TUBB2B
- TUBB3
- TUBB4A
- TUBB4B
- TUBB6
- TUBB8
- TUBA1A
- TUBA1B
- TUBA1C
Mechanisms of action (all sources)
- TUBB4B INHIBITOR
- TUBB1 INHIBITOR
- TUBA3C INHIBITOR
- TUBA4A INHIBITOR
- TUBB3 INHIBITOR
- TUBA1A INHIBITOR
- TUBB4A INHIBITOR
- TUBB8 INHIBITOR
- TUBB INHIBITOR
- TUBA1B INHIBITOR
- TUBA1C INHIBITOR
- TUBA3E INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
ATC classes
- L01C · PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Cross-references
Synonyms
- javlor
- vinflunine ditartrate
- Vinflunina
- Javlor (TN)
- Javlor
- 20',20'-difluoro-3',4'-dihydrovinorelbine
- CHEBI:90241
- 4'-Deoxy-20',20'-difluoro-C'-norvincaleukoblastine
- 5BF646324K
- methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-4-[(12S,14S,16R)-16-(1,1-difluoroethyl)-12-methoxycarbonyl-1,10-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraen-12-yl]-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
- 4'-deoxy-20',20'-difluoro-5'-norvincaleukoblastine
- 4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine
- Vinflunine [INN]
- Vinflunine [INN:BAN]
- vinflunina
- vinfluninum
- UNII-5BF646324K
- L-0070
- VINFLUNINE [MI]
- VINFLUNINE [MART.]
- VINFLUNINE [WHO-DD]
- VINFLUNINE [EMA EPAR]
- CHEMBL2110725
- DTXSID30936722
- HY-B0628
- ZINC85537078
- DB11641
- EN300-33343034
- C'-Norvincaleukoblastine, 4'-deoxy-20',20'-difluoro-
- 4'-DEOXY-20',20'-DIFLUORO-8'-NORVINCALEUCOBLASTINE
- methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-4-[(12S,14S,16R)-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^{3,11}.0^{4,9}]octadeca-3(11),4(9),5,7-tetraen-12-yl]-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
- methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(12S,14S,16R)-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0(3,11).0(4,9)]octadeca-3(11),4,6,8-tetraen-12-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
- methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-4-[(12S,14R,16R)-16-(1,1-difluoroethyl)-12-methoxycarbonyl-1,10-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraen-12-yl]-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
- SCHEMBL8403
- ZINC95627889
- NCGC00346580-02
- 652V951
- Q-101876
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