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EMPAGLIFLOZIN
SynDRA canonical compound SYN0033274 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | SLC5A2 |
|---|
| Mechanism of action | Sodium/glucose cotransporter inhibitor |
|---|
| Indication | diabetes mellitus |
|---|
| Disease area | endocrinology |
|---|
All known targets
- SLC5A2
- SLC5A1
- SLC5A10
- SLC5A11
- SLC5A9
Mechanisms of action (all sources)
- Sodium/glucose cotransporter inhibitor
- SLC5A2 INHIBITOR
- Sodium/glucose cotransporter 2 inhibitor
- SLC5A2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABL1
- PDE3A
- HTR1A
- HTR2B
- KCNH2
- KDR
- MAOA
- MAPK1
- OPRM1
- PDE4A
- ACHE
- PGR
- PTGS1
- SCN5A
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- HRH3
- HDAC6
- GSK3B
- FGFR2
- ADORA3
- ADRA1A
- ADRA2A
- AR
- AURKA
- BRD4
- BRPF1
- CDK2
- CHRM1
- CHRM2
- CSNK1D
- DRD1
- DRD3
- ESR1
- F2
- TRIM24
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Hypoglycemic Agents
- Sodium-Glucose Transporter 2 Inhibitors
- Sodium-Glucose Cotransporter 2 Inhibitor
ATC classes
- A10B · BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Cross-references
Synonyms
- EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE
- GLYXAMBI
- JARDIANCE
- Jardiance
- SYNJARDY
- SYNJARDY XR
- TRIJARDY XR
- BI 10773
- jardiance
- Empagliflozine
- Empagliflozina
- Bi10773
- Bi 10773
- Empagliflozin component of glyxambi
- Empagliflozin component of synjardy
- Empagliflozin component of trijardy xr
- BI-10773
- UNII-HDC1R2M35U
- Empagliflozin (BI 10773)
- BI10773
- HDC1R2M35U
- CHEBI:82720
- AK160980
- TRIJARDY XR COMPONENT EMPAGLIFLOZIN
- GLYXAMBI COMPONENT EMPAGLIFLOZIN
- Empagliflozinum
- RefChem:5790
- A10BK03
- DTXCID901510350
- MFCD22566222
- C23H27ClO7
- Empagliflozin [INN]
- Empagliflozin [USAN:INN]
- Jardiance (TN)
- 7R3
- Empagliflozin (Standard)
- EMPAGLIFLOZIN [MI]
Reported adverse events
- Angioedema
- Constipation
- Thirst
- Urinary tract infection
- Hypersensitivity
- Arthralgia
- Fournier's gangrene
- Ketoacidosis
- Nausea
- Phimosis
- Pyelonephritis
- Upper respiratory tract infection
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