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IBUPROFEN PICONOL
SynDRA canonical compound SYN0032007 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Cyclooxygenase inhibitor |
|---|
| Indication | pain relief |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- PTGS1
- PTGS2
- ASIC1
- SLC36A1
- SLC5A8
- CYP2C8
- CXCR1
- CXCR2
- CXCL8
- CYP2C9
- AKR1C2
- AKR1C3
Mechanisms of action (all sources)
- Cyclooxygenase inhibitor
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- ASIC1 MODULATOR
- SLC36A1 INHIBITOR
- SLC5A8 INHIBITOR
- CXCR1 INHIBITOR
- CXCR2 INHIBITOR
- CXCL8 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- HTR2B
- SLC6A4
- SLC6A3
- SLC6A2
- PGR
- PDE4A
- PDE3A
- OPRM1
- MAOA
- KDR
- KCNH2
- HTR1A
- ADORA3
- HRH3
- F2
- ESR1
- DRD1
- CHRM2
- CHRM1
- AR
- AGTR2
- ADRA2A
- ADRA1A
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ANDR
- CP1A2
- CP2C9
- CP2CJ
- CP3A7
Drug classes
- Cyclooxygenase Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Central Nervous System Agents
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Sensory System Agents
- Nonsteroidal Anti-inflammatory Drug
ATC classes
- G02C · OTHER GYNECOLOGICALS
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
- R02A · THROAT PREPARATIONS
- C01E · OTHER CARDIAC PREPARATIONS
- OPIOIDS
Cross-references
Synonyms
- pimeprofen
- staderm
- Pimeprofen
- Staderm
- BE-100
- U-75630
- ibuprofen-piconol
- pyridin-2-ylmethyl 2-[4-(2-methylpropyl)phenyl]propanoate
- Be 100
- B0F91K5U4N
- U 75630
- DTXCID703140
- pyridin-2-ylmethyl 2-(4-(2-methylpropyl)phenyl)propanoate
- RefChem:923256
- IBUPROFENPICONOL
- Vesicum
- pyridin-2-ylmethyl 2-(4-isobutylphenyl)propanoate
- 2-Pyridylmethyl 2-(4-isobutylphenyl)propionate
- 2-pyridylmethyl 2-(4-isobutylphenyl)propanoate
- MFCD00866018
- (pyridin-2-yl)methyl 2-[4-(2-methylpropyl)phenyl]propanoate
- Ibuprofen piconol [USAN:JAN]
- EINECS 264-979-8
- UNII-B0F91K5U4N
- Pineprofen
- 2-(p-Isobutylphenyl)propionic acid 2-pyridylmethyl ester
- Staderm (TN)
- 2-Pyridylmethyl 2-(p-(2-methylpropyl)phenyl)propionate
- Propionic acid, 2-(p-isobutylphenyl)-, 2-pyridylmethyl ester
- 2-pyridinylmethyl 2-(4-isobutylphenyl)propanoate
- SCHEMBL36747
- IBUPROFEN PICONOL [JAN]
- IBUPROFEN PICONOL [USAN]
- CHEBI:31685
- Ibuprofen piconol (JP17/USAN)
- HMS5085K22
- IBUPROFEN PICONOL [WHO-DD]
Reported adverse events
- Bleeding
- GI bleed
- Ulceration
- Perforation
- Elderly
- Addiction
- NGS
- Nausea
- Rash
- Depression
- Dizziness
- Dry eye
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