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PROGLUMETACIN
SynDRA canonical compound SYN0031658 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | PTGS1 | PTGS2 |
|---|
| Mechanism of action | cyclooxygenase inhibitor |
|---|
| Indication | pain relief |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- PTGS1
- PTGS2
- PTGDR2
- PPARG
- SLC46A1
- GLO1
- PLA2G2A
- PPARA
- PTGR2
- Ptgs2
- ABCB1
- ABCC1
Mechanisms of action (all sources)
- cyclooxygenase inhibitor
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- PTGDR2 FULL AGONIST
- PPARG PARTIAL AGONIST
- SLC46A1 INHIBITOR
- PTGS2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADRB2
- AHR
- RARA
- PPARD
- NR1I2
- KSYK
- KCNH2
- GLI3
- ESRRA
- ESR1
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CASP7
- CASP3
- ATXN2
- ANDR
- SYK
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Cyclooxygenase Inhibitors
- Cardiovascular Agents
- Enzyme Inhibitors
- Gout Suppressants
- Reproductive Control Agents
ATC classes
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
- C01E · OTHER CARDIAC PREPARATIONS
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
- S01B · ANTIINFLAMMATORY AGENTS
- ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Cross-references
Synonyms
- proglumetacin maleate
- proglumetacin dimaleate
- protacine
- afloxan
- CR 604
- Proglumetacine
- Proglumetacina
- Protacine
- Afloxan
- Proglumetacina [Spanish]
- EINECS 261-656-3
- CR-604
- AC1O5NKY
- 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-2-(4-(3-((4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl)oxy)propyl)-1-piperazinyl)ethyl ester (+-)-, (Z)-2-butenedioate (1:2)
- 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate
- Proglumetacinum
- FV919079LU
- DTXCID3028768
- CHEBI:76263
- RefChem:176175
- M01AB14
- Proglumetacin (INN)
- NCGC00183024-01
- PROGLUMETACIN [INN]
- Proglumetacin [INN:BAN]
- Proglumetacine [INN-French]
- Proglumetacinum [INN-Latin]
- Proglumetacina [INN-Spanish]
- UNII-FV919079LU
- Bruxel (TN)
- PROGLUMETACIN [MI]
- SCHEMBL27106
- PROGLUMETACIN [WHO-DD]
- SCHEMBL29384391
- PTXGHCGBYMQQIG-UHFFFAOYSA-N
- Tox21_113325
- CAS-57132-53-3
- HY-106560
Reported adverse events
- Bleeding
- GI bleed
- Perforation
- Ulceration
- Elderly
- Thrombophlebitis
- Stevens-Johnson syndrome
- Hypertension
- Headache
- Hepatotoxicity
- Pruritus
- Asthma
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