← SynDRA

SONIDEGIB

SynDRA canonical compound SYN0031598 — structure-anchored drug synonym record

All known targets

• SMO
• Shh

Mechanisms of action (all sources)

• Smoothened receptor antagonist
• SMO inhibitor
• Smoothened homolog inhibitor
• SMO ANTAGONIST
• SMO MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• GPR183
• ADGRF1
• HTR2C
• NEIL2
• NEIL1
• MLNR
• MC4R
• MC3R
• KCNH2
• HTR3A
• HTR2B
• NPY2R
• HTR2A
• HTR1A
• HRH3
• HRH2
• HRH1
• HDAC6
• GPR35
• NPY1R
• NR3C1
• ADORA1
• NTHL1
• TBXA2R
• TACR1
• SMUG1
• SLC6A4
• SLC6A3
• SLC6A2
• SLC29A1
• S1PR1
• PTGS2
• PGR
• PDE4D
• PDE3A
• OPRM1
• OPRK1
• OPRD1
• OGG1
• NTSR1

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• KSYK
• SYK

Drug classes

• Smoothened Receptor Antagonists
• Hedgehog Pathway Inhibitor

ATC classes

• L01X · OTHER ANTINEOPLASTIC AGENTS

Cross-references

• PubChem CID: 24775005
• ChEMBL: CHEMBL2105737
• DrugBank: DB09143
• ChEBI: CHEBI:90863
• KEGG: D10119
• RxNorm: 1659191
• Wikipedia: Sonidegib
• TTD: D09BNZ
• LINCS BRD: BRD-K19796430

Synonyms

• ODOMZO
• Odomzo
• sonidegib diphosphate
• odomzo
• LDE225
• erismodegib
• LDE-225
• NPV-LDE-225
• sonidegib phosphate
• NVP-LDE-225
• NVP-LDE225
• Erismodegib
• LDE 225
• Sonidegib (LDE-225)
• LDE225 (NVP-LDE225,Erismodegib)
• 0RLU3VTK5M
• LDE225 Diphosphate
• 956697-53-3 (free base)
• Odomozo
• Sonidegib [USAN:INN]
• UNII-0RLU3VTK5M
• Erismodegib [USAN:INN]
• Sonidegib phospate
• LDE225 (NVP-LDE225; Erismodegib)
• SONIDEGIB [INN]
• SONIDEGIB [MI]
• Sonidegib (USAN/INN)
• SONIDEGIB [USAN]
• erismodegib (deleted INN)
• SONIDEGIB [WHO-DD]
• NVP-LDE225(Erismodegib)
• Sonidegib (NVP-LDE225)
• MLS006011198
• SCHEMBL554455
• GTPL8199
• CHEMBL2105737
• CHEBI:90863
• EX-A409

Reported adverse events

• Abdominal pain
• Alopecia
• Dysgeusia
• Fatigue
• Headache
• Muscle spasms
• Musculoskeletal pain
• Myalgia
• Nausea
• Pruritus
• Vomiting
• Decreased appetite